Viral Pathogenesis and Immunity

  • Filename: viral-pathogenesis-and-immunity.
  • ISBN: 9780080471051
  • Release Date: 2007-04-04
  • Number of pages: 280
  • Author: Neal Nathanson
  • Publisher: Academic Press

Based on the highly successful reference work Viral Pathogenesis published in 1997, this concise, economical version can be used both as an introductory text or for self-education by medical students and biologists alike. This latest edition provides a completely revised overview of the subject with new chapters on innate immunity, emerging viral diseases, and antiviral therapy in a format that is easy to understand without continually referring to additional information. Used by the author in his graduate classes at the University of Pennsylvania, it sets forth the essential principles and discusses the details of how the immune system responds to viral invasion including the treatment and prevention of infection. Illustrated by pertinent examples it is one of the only books devoted exclusively to this topic. * Offers almost a 20% expansion over the first edition * Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic * Neal Nathanson is one of the primary authorities in the field and has authored chapters on viral pathogenesis in two of the most well known virology and microbiology titles Field's Virology and Topley and Wilson's Microbiology * Now in four color throughout!

West Nile Encephalitis Virus Infection

  • Filename: west-nile-encephalitis-virus-infection.
  • ISBN: 0387798404
  • Release Date: 2009-02-12
  • Number of pages: 485
  • Author: Michael S. Diamond
  • Publisher: Springer Science & Business Media

West Nile virus is a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Infection of humans and other vertebrate animals is associated with a febrile illness that can progress to a lethal encephalitis or flaccid paralysis syndrome. Its appearance in the Western Hemisphere in 1999 and the corresponding increase in global disease burden over the last decade have been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. Studies in mammalian systems have dissected the viral and host factors that determine the pathogenesis and outcome of West Nile virus infection. On the basis of these experiments, progress has been made on the identification of genetic factors that predispose to severe human disease. Thus, in a remarkably short period of time, insight has been gained on a wide variety of disciplines related to West Nile virus biology. The aim of this book was to assemble an up-to-date and cutti- edge anthology from the leading experts in the field. The chapters are balanced by submissions from newcomers who have made significant recent contributions with those from established investigators who have dedicated their careers to the study of West Nile virus.

Viral Pathogenesis

  • Filename: viral-pathogenesis.
  • ISBN: 0128009640
  • Release Date: 2016-01-15
  • Number of pages: 304
  • Author: Michael Katze
  • Publisher: Academic Press

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

The Flaviviruses Pathogenesis and Immunity

  • Filename: the-flaviviruses-pathogenesis-and-immunity.
  • ISBN: 9780080493824
  • Release Date: 2003-12-18
  • Number of pages: 486
  • Author:
  • Publisher: Academic Press

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family

Concepts in Viral Pathogenesis

  • Filename: concepts-in-viral-pathogenesis.
  • ISBN: 9781461252504
  • Release Date: 2012-12-06
  • Number of pages: 409
  • Author: A. L. Notkins
  • Publisher: Springer Science & Business Media

The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

Viral Pathogenesis in Diagrams

  • Filename: viral-pathogenesis-in-diagrams.
  • ISBN: 1420039113
  • Release Date: 2000-11-29
  • Number of pages: 264
  • Author: Hans-Wolfgang Ackermann
  • Publisher: CRC Press

Viral Pathogenesis in Diagrams is the first book of its kind to illustrate viral pathogenesis on a comparative basis. The text covers the pathogenesis of viral diseases, including vertebrates, invertebrates, plants, and protists. The diagrams summarize and integrate large numbers of observations, from electron microscopy to clinical data, into a single picture or a few related drawings. Organized alphabetically by virus family or groups, this book covers the complete domain of virology. Transcending photographs and experimental data, the diagrams are ideally suited to illustrate the pathogenesis of viral diseases, from infection to host defenses and cell death. Included are two chapters describing general pathogenesis in vertebrate virus infections and illustrating the spread of viruses through the body, as well as cytopathology and host defenses. One chapter illustrates the pathogenic behavior of 19 vertebrate virus families, especially herpesviruses and retroviruses. The 268 diagrams in Viral Pathogenesis in Diagrams were selected from over 800 diagrams of English and French virological literature, including one derived from a famous drawing by Leonardo da Vinci. This up-to-date reference will promote understanding and future research.

Multichain Immune Recognition Receptor Signaling

  • Filename: multichain-immune-recognition-receptor-signaling.
  • ISBN: 9780387097893
  • Release Date: 2008-12-16
  • Number of pages: 357
  • Author: Alexander Sigalov
  • Publisher: Springer Science & Business Media

This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Mims Pathogenesis of Infectious Disease

  • Filename: mims-pathogenesis-of-infectious-disease.
  • ISBN: 0124982654
  • Release Date: 2001
  • Number of pages: 474
  • Author: Cedric A. Mims
  • Publisher: Gulf Professional Publishing

Infectious diseases are the leading cause of death worldwide, and are increasing in almost every nation, including the United States; they ranked third among the leading causes of death in the U.S. in 1992. Infectious diseases can be caused by bacteria, parasites, viruses, and other microbes such as fungus. They are part of everyday life, and range in severity from strep throat to AIDS. Mims' Pathogenesis of Infectious Disease has been the landmark book in the field. This revised edition provides an up-to-date picture of the global burden of infectious disease. It explains principles clearly and completely, using examples from various infections. It covers the mechanisms for spread of disease, immune response, and recovery, and is ideal as a course text for graduate and undergraduate students. New features include: * Microbial gene sequencing * Role of bacterial virulence factors in vivo * Latest data on tuberculosis - the number one infectious disease worldwide * Role of pathogenic cytokines * Significance of toxins * An update on vaccines, prions, immune evasion, microbial ligands and receptors


  • Filename: rabies.
  • ISBN: 0080550096
  • Release Date: 2010-07-26
  • Number of pages: 680
  • Author: William H. Wunner
  • Publisher: Academic Press

Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes. * Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis * More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year * New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled * Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed * Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation * Includes an increase in illustrations to more accurately represent this diseases’ unique horror

Molecular Biology of the Cell

  • Filename: molecular-biology-of-the-cell.
  • ISBN: 0815344325
  • Release Date: 2014-11-18
  • Number of pages: 1464
  • Author: Bruce Alberts
  • Publisher: Garland Science

"As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens"--Provided by publisher.

Human Herpesviruses

  • Filename: human-herpesviruses.
  • ISBN: 9781139461641
  • Release Date: 2007-08-16
  • Number of pages:
  • Author: Ann Arvin
  • Publisher: Cambridge University Press

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Systemic Lupus Erythematosus From Immunopathology to Viral Pathogenesis

  • Filename: systemic-lupus-erythematosus-from-immunopathology-to-viral-pathogenesis.
  • ISBN: 1109225075
  • Release Date: 2008
  • Number of pages: 235
  • Author:
  • Publisher: ProQuest

The first section of this research study aimed to explore the messengers that influence Th1/Th2 cells differentiation, development, effector functions and hence their plausible contribution in SLE immunopathogenesis. We focused on studying the expression of cytokine and chemokine milieu that directs the traffic of T lymphocytes; co-stimulatory molecules in the activation of T lymphocytes; transcription factors T-bet and GATA-3 in regulating the differentiation of Th1 and Th2 cell lineage. We also investigated the involvement of the lymphocyte subpopulation, Th17 in the auto-inflammatory axis of SLE exacerbation.

How Pathogenic Viruses Work

  • Filename: how-pathogenic-viruses-work.
  • ISBN: 0763720828
  • Release Date: 2002
  • Number of pages: 115
  • Author: Lauren Sompayrac
  • Publisher: Jones & Bartlett Learning

A clever, accessible overview that uses a survey of 12 of the most common viral infections, to teach the fundamental principles of human virology.

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