Viral Pathogenesis and Immunity

  • Filename: viral-pathogenesis-and-immunity.
  • ISBN: 9780080471051
  • Release Date: 2007-04-04
  • Number of pages: 280
  • Author: Neal Nathanson
  • Publisher: Academic Press



Based on the highly successful reference work Viral Pathogenesis published in 1997, this concise, economical version can be used both as an introductory text or for self-education by medical students and biologists alike. This latest edition provides a completely revised overview of the subject with new chapters on innate immunity, emerging viral diseases, and antiviral therapy in a format that is easy to understand without continually referring to additional information. Used by the author in his graduate classes at the University of Pennsylvania, it sets forth the essential principles and discusses the details of how the immune system responds to viral invasion including the treatment and prevention of infection. Illustrated by pertinent examples it is one of the only books devoted exclusively to this topic. * Offers almost a 20% expansion over the first edition * Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic * Neal Nathanson is one of the primary authorities in the field and has authored chapters on viral pathogenesis in two of the most well known virology and microbiology titles Field's Virology and Topley and Wilson's Microbiology * Now in four color throughout!

Viral Pathogenesis

  • Filename: viral-pathogenesis.
  • ISBN: 0128009640
  • Release Date: 2016-01-15
  • Number of pages: 304
  • Author: Michael Katze
  • Publisher: Academic Press



Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Viral Pathogenesis in Diagrams

  • Filename: viral-pathogenesis-in-diagrams.
  • ISBN: 1420039113
  • Release Date: 2000-11-29
  • Number of pages: 264
  • Author: Hans-Wolfgang Ackermann
  • Publisher: CRC Press



Viral Pathogenesis in Diagrams is the first book of its kind to illustrate viral pathogenesis on a comparative basis. The text covers the pathogenesis of viral diseases, including vertebrates, invertebrates, plants, and protists. The diagrams summarize and integrate large numbers of observations, from electron microscopy to clinical data, into a single picture or a few related drawings. Organized alphabetically by virus family or groups, this book covers the complete domain of virology. Transcending photographs and experimental data, the diagrams are ideally suited to illustrate the pathogenesis of viral diseases, from infection to host defenses and cell death. Included are two chapters describing general pathogenesis in vertebrate virus infections and illustrating the spread of viruses through the body, as well as cytopathology and host defenses. One chapter illustrates the pathogenic behavior of 19 vertebrate virus families, especially herpesviruses and retroviruses. The 268 diagrams in Viral Pathogenesis in Diagrams were selected from over 800 diagrams of English and French virological literature, including one derived from a famous drawing by Leonardo da Vinci. This up-to-date reference will promote understanding and future research.

West Nile Encephalitis Virus Infection

  • Filename: west-nile-encephalitis-virus-infection.
  • ISBN: 0387798390
  • Release Date: 2008-12-02
  • Number of pages: 485
  • Author: Michael S. Diamond
  • Publisher: Springer



West Nile virus is a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Infection of humans and other vertebrate animals is associated with a febrile illness that can progress to a lethal encephalitis or flaccid paralysis syndrome. Its appearance in the Western Hemisphere in 1999 and the corresponding increase in global disease burden over the last decade have been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. Studies in mammalian systems have dissected the viral and host factors that determine the pathogenesis and outcome of West Nile virus infection. On the basis of these experiments, progress has been made on the identification of genetic factors that predispose to severe human disease. Thus, in a remarkably short period of time, insight has been gained on a wide variety of disciplines related to West Nile virus biology. The aim of this book was to assemble an up-to-date and cutti- edge anthology from the leading experts in the field. The chapters are balanced by submissions from newcomers who have made significant recent contributions with those from established investigators who have dedicated their careers to the study of West Nile virus.

Multichain Immune Recognition Receptor Signaling

  • Filename: multichain-immune-recognition-receptor-signaling.
  • ISBN: 9780387097893
  • Release Date: 2008-12-16
  • Number of pages: 357
  • Author: Alexander Sigalov
  • Publisher: Springer Science & Business Media



This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

The Flaviviruses Pathogenesis and Immunity

  • Filename: the-flaviviruses-pathogenesis-and-immunity.
  • ISBN: 9780080493824
  • Release Date: 2003-12-18
  • Number of pages: 486
  • Author:
  • Publisher: Academic Press



Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family

Viral Immunity

  • Filename: viral-immunity.
  • ISBN: 1612830404
  • Release Date: 2002-08-01
  • Number of pages: 496
  • Author: J. E. Williams
  • Publisher: Hampton Roads Publishing



HIV, hepatitis, influenza, the common cold, herpes, Ebola, Hantavirus, West Nile fever, dengue, TT virus--the viral world keeps posing new major challenges to human health each year. At the same time as this onslaught of emerging powerful viral infections, our antibiotic arsenals are losing ground and our immune systems are compromised. Can we handle the next viral epidemic? Yes, says James Williams, an experienced, credentialled naturopath, acupuncturist, and expert in traditional Chinese medicine. We can shore up our immune system to handle current and any future viral infections and not be dependent on conventional vaccinations or antibiotics to insure our health. In 10 practical steps, Dr. Williams shows how to develop unassailable viral immunity using natural approaches. If you already have a viral infection, these steps will help you reverse its effects; if you're concerned about exposure to one in the future, these steps will give you the keys to prevention. Included in these steps are the best that natural medicine offers: stress management, enzymes, nutrients, detoxification, oxygen therapy, immune modulators, hormones, natural antiviral medicines and anti-inflammatory medicines, Chinese and Western herbs, and more. "Viral immunity is without question one of the most important health issues of this century," says Dr. Williams. "The message of this book is clear. You can improve your system in general with diet, lifestyle, and natural medicines. Here you will find natural ways of improving immune function, remedies to treat viral infections, and suggestions on how to reframe outdated concepts that could otherwise prevent you from obtaining effective treatment."

Molecular Biology of the Cell

  • Filename: molecular-biology-of-the-cell.
  • ISBN: 0824036956
  • Release Date: 1989
  • Number of pages: 1263
  • Author: Bruce Alberts
  • Publisher: Courier Corporation



New edition of a text in which six researchers from leading institutions discuss what is known and what is yet to be understood in the field of cell biology. The material on molecular genetics has been revised and expanded so that it can be used as a stand-alone text. A new chapter covers pathogens, infection, and innate immunity. Topics include introduction to the cell, basic genetic mechanisms, methods, internal organization of the cell, and cells in their social context. The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.

The Role of Immunity to Mosquito Salivary Proteins in the Pathogenesis of Flaviviruses Flavivirus Flaviviridae

  • Filename: the-role-of-immunity-to-mosquito-salivary-proteins-in-the-pathogenesis-of-flaviviruses-flavivirus-flaviviridae.
  • ISBN: 9780549445906
  • Release Date: 2007
  • Number of pages: 167
  • Author:
  • Publisher: ProQuest



Mosquito salivary proteins were obtained by a novel technique involving collection in a salivation buffer and concentration by trichloroacetic acid (TCA) precipitation. Immunoreactive proteins from Cx. tarsalis and Ae. aegypti were proposed to be related to viral pathogenesis.

West Nile Encephalitis Virus Infection

  • Filename: west-nile-encephalitis-virus-infection.
  • ISBN: 0387798404
  • Release Date: 2009-02-12
  • Number of pages: 485
  • Author: Michael S. Diamond
  • Publisher: Springer Science & Business Media



West Nile virus is a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Infection of humans and other vertebrate animals is associated with a febrile illness that can progress to a lethal encephalitis or flaccid paralysis syndrome. Its appearance in the Western Hemisphere in 1999 and the corresponding increase in global disease burden over the last decade have been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. Studies in mammalian systems have dissected the viral and host factors that determine the pathogenesis and outcome of West Nile virus infection. On the basis of these experiments, progress has been made on the identification of genetic factors that predispose to severe human disease. Thus, in a remarkably short period of time, insight has been gained on a wide variety of disciplines related to West Nile virus biology. The aim of this book was to assemble an up-to-date and cutti- edge anthology from the leading experts in the field. The chapters are balanced by submissions from newcomers who have made significant recent contributions with those from established investigators who have dedicated their careers to the study of West Nile virus.

Viruses and Interferon

  • Filename: viruses-and-interferon.
  • ISBN: 9781904455813
  • Release Date: 2011
  • Number of pages: 265
  • Author: Karen Mossman
  • Publisher: Horizon Scientific Press



Interferons (IFNs) play pivotal roles in shaping the immune responses in mammals and are particularly important for the control of viral infections, cell growth, and immune regulation. These proteins rapidly induce an "anti-viral state" in cells that surround infected cells. In order to survive, viruses have evolved with multiple strategies to evade the anti-viral effects of IFNs. Elucidating the molecular and cellular biology of the virus-interferon interaction is key to understanding issues, such as viral pathogenesis, latency, and the development of novel antivirals. In this book, international experts review current research topics, producing a timely overview of this exciting field. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA - the "viral toxin." This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. Additional chapters are devoted to understanding the diverse strategies used by clinically-relevant human viruses to subvert host interferon responses. The book closes with an interesting overview of the clinical application of interferons as antiviral and anticancer agents. It will be essential reading for every scientist involved in interferon or antiviral research and will be a recommended text for all virology laboratories.

Humanized Mice for HIV Research

  • Filename: humanized-mice-for-hiv-research.
  • ISBN: 9781493916559
  • Release Date: 2015-02-18
  • Number of pages: 538
  • Author: Larisa Y. Poluektova
  • Publisher: Springer



Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

Complement Directs Both the Priming and Effector Functions of WNV specific Antibody

  • Filename: complement-directs-both-the-priming-and-effector-functions-of-wnv-specific-antibody.
  • ISBN: 9780549646501
  • Release Date: 2008
  • Number of pages: 210
  • Author:
  • Publisher: ProQuest



West Nile virus (WNV) is a neurotropic flavivirus that causes severe infection of the central nervous system (CNS) in humans, primarily the elderly and immunocompromised. Stimulation of adaptive immunity to WNV is critical for host protection from disease. The complement system is a central component of humoral innate immunity that also has known roles stimulating adaptive immune responses to viral infection. The central aims of this thesis were to dissect the role of complement activation in priming immune responses necessary to restrict West Nile virus disease, and to determine the role of complement in modulating the function of WNV-specific antibody. To determine the contributions of the individual complement activation pathways to the protection from WNV disease, genetically deficient mice were infected. The absence of C3, CR1/2, C1q, C4, factor B (fB), or factor D (fD) all resulted in increased mortality in mice, suggesting that all three activation pathways are necessary to limit WNV spread. However, differences in virologic and immunologic phenotypes were observed. In the absence of alternative pathway activation, reduced CD8+ T cell responses were observed. In contrast, animals lacking the classical and lectin pathways had deficits in both B and T cell responses to WNV. Finally, and somewhat surprisingly, C1q was required for productive infection in the spleen, but not for development of adaptive immune responses following WNV infection. Taken together, these results indicate that individual pathways of complement activation control WNV infection by priming adaptive immune responses through distinct mechanisms. To examine the role of complement in modulating the function of antiviral antibody, WNV reporter virus particle infection in the presence and absence of antibody and complement was assayed. C1q was necessary and sufficient to both augment neutralization and restrict antibody-dependent enhancement of infection by anti-flavivirus antibodies in an IgG subclass-specific manner. IgG subclasses that bound C1q avidly induced minimal antibody-dependent enhancement (ADE) in the presence of C1q, whereas subclasses that bind C1q weakly strongly enhance infection. Together, these studies establish complement-dependent priming and effector functions are critical for restricting West Nile virus replication and pathogenesis. These studies identify an unappreciated layer of complexity for the analysis of humoral immunity and flavivirus infection.

Mims Pathogenesis of Infectious Disease

  • Filename: mims-pathogenesis-of-infectious-disease.
  • ISBN: 0124982654
  • Release Date: 2001
  • Number of pages: 474
  • Author: Cedric A. Mims
  • Publisher: Gulf Professional Publishing



Infectious diseases are the leading cause of death worldwide, and are increasing in almost every nation, including the United States; they ranked third among the leading causes of death in the U.S. in 1992. Infectious diseases can be caused by bacteria, parasites, viruses, and other microbes such as fungus. They are part of everyday life, and range in severity from strep throat to AIDS. Mims' Pathogenesis of Infectious Disease has been the landmark book in the field. This revised edition provides an up-to-date picture of the global burden of infectious disease. It explains principles clearly and completely, using examples from various infections. It covers the mechanisms for spread of disease, immune response, and recovery, and is ideal as a course text for graduate and undergraduate students. New features include: * Microbial gene sequencing * Role of bacterial virulence factors in vivo * Latest data on tuberculosis - the number one infectious disease worldwide * Role of pathogenic cytokines * Significance of toxins * An update on vaccines, prions, immune evasion, microbial ligands and receptors

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