Viral Pathogenesis and Immunity

  • Filename: viral-pathogenesis-and-immunity.
  • ISBN: 9780080471051
  • Release Date: 2007-04-04
  • Number of pages: 280
  • Author: Neal Nathanson
  • Publisher: Academic Press

Based on the highly successful reference work Viral Pathogenesis published in 1997, this concise, economical version can be used both as an introductory text or for self-education by medical students and biologists alike. This latest edition provides a completely revised overview of the subject with new chapters on innate immunity, emerging viral diseases, and antiviral therapy in a format that is easy to understand without continually referring to additional information. Used by the author in his graduate classes at the University of Pennsylvania, it sets forth the essential principles and discusses the details of how the immune system responds to viral invasion including the treatment and prevention of infection. Illustrated by pertinent examples it is one of the only books devoted exclusively to this topic. * Offers almost a 20% expansion over the first edition * Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic * Neal Nathanson is one of the primary authorities in the field and has authored chapters on viral pathogenesis in two of the most well known virology and microbiology titles Field's Virology and Topley and Wilson's Microbiology * Now in four color throughout!

Viral Pathogenesis

  • Filename: viral-pathogenesis.
  • ISBN: 0128009640
  • Release Date: 2016-01-15
  • Number of pages: 304
  • Author: Michael Katze
  • Publisher: Academic Press

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

The Flaviviruses Pathogenesis and Immunity

  • Filename: the-flaviviruses-pathogenesis-and-immunity.
  • ISBN: 9780080493824
  • Release Date: 2003-12-18
  • Number of pages: 486
  • Author:
  • Publisher: Academic Press

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family

West Nile Encephalitis Virus Infection

  • Filename: west-nile-encephalitis-virus-infection.
  • ISBN: 0387798404
  • Release Date: 2009-02-12
  • Number of pages: 485
  • Author: Michael S. Diamond
  • Publisher: Springer Science & Business Media

West Nile virus is a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Infection of humans and other vertebrate animals is associated with a febrile illness that can progress to a lethal encephalitis or flaccid paralysis syndrome. Its appearance in the Western Hemisphere in 1999 and the corresponding increase in global disease burden over the last decade have been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. Studies in mammalian systems have dissected the viral and host factors that determine the pathogenesis and outcome of West Nile virus infection. On the basis of these experiments, progress has been made on the identification of genetic factors that predispose to severe human disease. Thus, in a remarkably short period of time, insight has been gained on a wide variety of disciplines related to West Nile virus biology. The aim of this book was to assemble an up-to-date and cutti- edge anthology from the leading experts in the field. The chapters are balanced by submissions from newcomers who have made significant recent contributions with those from established investigators who have dedicated their careers to the study of West Nile virus.

Viral Pathogenesis in Diagrams

  • Filename: viral-pathogenesis-in-diagrams.
  • ISBN: 1420039113
  • Release Date: 2000-11-29
  • Number of pages: 264
  • Author: Hans-Wolfgang Ackermann
  • Publisher: CRC Press

Viral Pathogenesis in Diagrams is the first book of its kind to illustrate viral pathogenesis on a comparative basis. The text covers the pathogenesis of viral diseases, including vertebrates, invertebrates, plants, and protists. The diagrams summarize and integrate large numbers of observations, from electron microscopy to clinical data, into a single picture or a few related drawings. Organized alphabetically by virus family or groups, this book covers the complete domain of virology. Transcending photographs and experimental data, the diagrams are ideally suited to illustrate the pathogenesis of viral diseases, from infection to host defenses and cell death. Included are two chapters describing general pathogenesis in vertebrate virus infections and illustrating the spread of viruses through the body, as well as cytopathology and host defenses. One chapter illustrates the pathogenic behavior of 19 vertebrate virus families, especially herpesviruses and retroviruses. The 268 diagrams in Viral Pathogenesis in Diagrams were selected from over 800 diagrams of English and French virological literature, including one derived from a famous drawing by Leonardo da Vinci. This up-to-date reference will promote understanding and future research.

Multichain Immune Recognition Receptor Signaling

  • Filename: multichain-immune-recognition-receptor-signaling.
  • ISBN: 9780387097893
  • Release Date: 2008-12-16
  • Number of pages: 357
  • Author: Alexander Sigalov
  • Publisher: Springer Science & Business Media

This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Viruses and Interferon

  • Filename: viruses-and-interferon.
  • ISBN: 9781904455813
  • Release Date: 2011
  • Number of pages: 265
  • Author: Karen Mossman
  • Publisher: Horizon Scientific Press

Interferons (IFNs) play pivotal roles in shaping the immune responses in mammals and are particularly important for the control of viral infections, cell growth, and immune regulation. These proteins rapidly induce an "anti-viral state" in cells that surround infected cells. In order to survive, viruses have evolved with multiple strategies to evade the anti-viral effects of IFNs. Elucidating the molecular and cellular biology of the virus-interferon interaction is key to understanding issues, such as viral pathogenesis, latency, and the development of novel antivirals. In this book, international experts review current research topics, producing a timely overview of this exciting field. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA - the "viral toxin." This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. Additional chapters are devoted to understanding the diverse strategies used by clinically-relevant human viruses to subvert host interferon responses. The book closes with an interesting overview of the clinical application of interferons as antiviral and anticancer agents. It will be essential reading for every scientist involved in interferon or antiviral research and will be a recommended text for all virology laboratories.

The Role of Immunity to Mosquito Salivary Proteins in the Pathogenesis of Flaviviruses Flavivirus Flaviviridae

  • Filename: the-role-of-immunity-to-mosquito-salivary-proteins-in-the-pathogenesis-of-flaviviruses-flavivirus-flaviviridae.
  • ISBN: 9780549445906
  • Release Date: 2007
  • Number of pages: 167
  • Author:
  • Publisher: ProQuest

Mosquito salivary proteins were obtained by a novel technique involving collection in a salivation buffer and concentration by trichloroacetic acid (TCA) precipitation. Immunoreactive proteins from Cx. tarsalis and Ae. aegypti were proposed to be related to viral pathogenesis.

Humanized Mice for HIV Research

  • Filename: humanized-mice-for-hiv-research.
  • ISBN: 9781493916559
  • Release Date: 2015-02-18
  • Number of pages: 538
  • Author: Larisa Y. Poluektova
  • Publisher: Springer

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

Complement Directs Both the Priming and Effector Functions of WNV specific Antibody

  • Filename: complement-directs-both-the-priming-and-effector-functions-of-wnv-specific-antibody.
  • ISBN: 9780549646501
  • Release Date: 2008
  • Number of pages: 210
  • Author:
  • Publisher: ProQuest

West Nile virus (WNV) is a neurotropic flavivirus that causes severe infection of the central nervous system (CNS) in humans, primarily the elderly and immunocompromised. Stimulation of adaptive immunity to WNV is critical for host protection from disease. The complement system is a central component of humoral innate immunity that also has known roles stimulating adaptive immune responses to viral infection. The central aims of this thesis were to dissect the role of complement activation in priming immune responses necessary to restrict West Nile virus disease, and to determine the role of complement in modulating the function of WNV-specific antibody. To determine the contributions of the individual complement activation pathways to the protection from WNV disease, genetically deficient mice were infected. The absence of C3, CR1/2, C1q, C4, factor B (fB), or factor D (fD) all resulted in increased mortality in mice, suggesting that all three activation pathways are necessary to limit WNV spread. However, differences in virologic and immunologic phenotypes were observed. In the absence of alternative pathway activation, reduced CD8+ T cell responses were observed. In contrast, animals lacking the classical and lectin pathways had deficits in both B and T cell responses to WNV. Finally, and somewhat surprisingly, C1q was required for productive infection in the spleen, but not for development of adaptive immune responses following WNV infection. Taken together, these results indicate that individual pathways of complement activation control WNV infection by priming adaptive immune responses through distinct mechanisms. To examine the role of complement in modulating the function of antiviral antibody, WNV reporter virus particle infection in the presence and absence of antibody and complement was assayed. C1q was necessary and sufficient to both augment neutralization and restrict antibody-dependent enhancement of infection by anti-flavivirus antibodies in an IgG subclass-specific manner. IgG subclasses that bound C1q avidly induced minimal antibody-dependent enhancement (ADE) in the presence of C1q, whereas subclasses that bind C1q weakly strongly enhance infection. Together, these studies establish complement-dependent priming and effector functions are critical for restricting West Nile virus replication and pathogenesis. These studies identify an unappreciated layer of complexity for the analysis of humoral immunity and flavivirus infection.

HIV I Molecular Biology and Pathogenesis Clinical Applications

  • Filename: hiv-i-molecular-biology-and-pathogenesis-clinical-applications.
  • ISBN: 9780080557229
  • Release Date: 2007-12-14
  • Number of pages: 638
  • Author:
  • Publisher: Academic Press

Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad:HIV-1: Molecular Biology and Pathogenesis, 2E. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. * The latest developments in HIV-vaccine research * New concepts in the discovery and design of novel anti-HIV drugs

Infectious Diseases of the Fetus and Newborn

  • Filename: infectious-diseases-of-the-fetus-and-newborn.
  • ISBN: 9781437736373
  • Release Date: 2010-08-27
  • Number of pages: 1280
  • Author: Christopher B. Wilson
  • Publisher: Elsevier Health Sciences

Infectious Diseases of the Fetus and Newborn Infant, written and edited by Drs. Remington, Klein, Wilson, Nizet, and Maldonado, remains the definitive source of information in this field. The 7th edition of this authoritative reference provides the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants. Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization of the fetus/mother. Nationally and internationally recognized in immunology and infectious diseases, new associate editors Nizet and Maldonado bring new insight and fresh perspective to the book. Get the latest information on maternal infections when they are pertinent to the infant or developing fetus, including disease transmission through breastfeeding Diagnose, prevent, and treat neonatal infectious diseases with expert guidance from the world's leading authorities and evidence-based recommendations. Incorporate the latest findings about infections found in utero, during delivery, and in the neonatal period. Find the critical answers you need quickly and easily thanks to a consistent, highly user-friendly format Get fresh perspectives from two new associate editors—Drs. Yvonne Maldonado, head of the Pediatric Infectious Disease program at Stanford, and Victor Nizet, Professor of Pediatrics & Pharmacy at University of California, San Diego and UCSD School of Medicine. Keep up with the most relevant topics in fetal/neonatal infectious disease including new antimicrobial agents, gram- negative infections and their management, and recommendations for immunization of the fetus/mother. Overcome the clinical challenges in developing countries where access to proper medical care is limited. Apply the latest recommendations for H1N1 virus and vaccines. Identify and treat infections with the latest evidence-based information on fighting life-threatening diseases in the fetus and newborn infants.

Influenza Pathogenesis and Control

  • Filename: influenza-pathogenesis-and-control.
  • ISBN: 9783319111582
  • Release Date: 2014-11-06
  • Number of pages: 484
  • Author: Michael B. A. Oldstone
  • Publisher: Springer

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.

In vivo Models of HIV Disease and Control

  • Filename: in-vivo-models-of-hiv-disease-and-control.
  • ISBN: 9780387257419
  • Release Date: 2007-04-27
  • Number of pages: 436
  • Author: Herman Friedman
  • Publisher: Springer Science & Business Media

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

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