Justice and the Human Genome Project

  • Filename: justice-and-the-human-genome-project.
  • ISBN: 0520083636
  • Release Date: 1994
  • Number of pages: 178
  • Author: Timothy F. Murphy
  • Publisher: Univ of California Press

"In my view, [Murphy] has written the most incisive general critical essay on the Human Genome Project yet to appear."--Troy Duster, Director, Institute for the Study of Social Change, University of California, Berkeley "In my view, [Murphy] has written the most incisive general critical essay on the Human Genome Project yet to appear."--Troy Duster, Director, Institute for the Study of Social Change, University of California, Berkeley

Curiosity Guides The Human Genome

  • Filename: curiosity-guides-the-human-genome.
  • ISBN: 9781607343561
  • Release Date: 2011-02-01
  • Number of pages: 176
  • Author: John Quackenbush
  • Publisher: Charlesbridge

The DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's. Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease. In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth. Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.

The Book of Man

  • Filename: the-book-of-man.
  • ISBN: 9780195114874
  • Release Date: 1997-01
  • Number of pages: 259
  • Author: Walter Fred Bodmer
  • Publisher: Oxford University Press on Demand

James Watson, a discoverer of the structure of DNA, described it as "the most golden of molecules," the true chemical for life. Indeed, it is the essential component from which our genes are made. In it is encoded the genetic language that controls our destinies. Astonishingly powerful, just six millionths of a gram of DNA carries as much information as ten volumes of the Oxford English Dictionary. The "Book of Man," is the term used by Walter Bodmer and Robin McKie for the DNA that is the instruction set according to which all humans are made. At conception, a single cell--the fertilized egg--is produced, and it is this one cell that has the potential to form a new and unique individual under the guidance of the DNA within its nucleus. The human body is made up of a hundred million million cells of many different sorts, and all contain the inherited information that comes from that first, single cell created at fertilization. Bodmer and McKie assert that when we learn how to read DNA's pages and chapters we will obtain the information relevant to the understanding of most diseases, individual differences in behavior, and a new awareness of our own history and evolution. The Book of Man explores how genetic information is now being read and interpreted by focusing on biology's most ambitious undertaking to date--the Human Genome Project, an attempt to uncover all the 100,000 genes that control our development and detail the DNA alphabet of each. The authors go on to wrestle with the moral and ethical issues of modern genetics, making a case for a rational appraisal of genetic engineering and for the public to become sufficiently "DNA literate" in order to appreciate the crucial role it plays in our lives. From Gregor Mendel's discovery of the laws of inheritance to the high-tech, crime-stopping power of forensics science and the fascinating but sometimes troublesome implications of the latest science of genetic engineering, The Book of Man brilliantly explores and explains the quest that is changing our understanding of what it means to be a human being.

The Human Genome

  • Filename: the-human-genome.
  • ISBN: 0080918654
  • Release Date: 2010-12-12
  • Number of pages: 420
  • Author: Julia E. Richards
  • Publisher: Academic Press

Significant advances in our knowledge of genetics were made during the twentieth century but in the most recent decades, genetic research has dramatically increased its impact throughout society. Genetic issues are now playing a large role in health and public policy, and new knowledge in this field will continue to have significant implications for individuals and society. Written for the non-majors human genetics course, Human Genetics, 3E will increase the genetics knowledge of students who are learning about human genetics for the first time. This thorough revision of the best-selling Human Genome,2E includes entirely new chapters on forensics, stem cell biology, bioinformatics, and societal/ethical issues associated with the field. New special features boxes make connections between human genetics and human health and disease. Carefully crafted pedagogy includes chapter-opening case studies that set the stage for each chapter; concept statements interspersed throughout the chapter that keep first-time students focused on key concepts; and end-of-chapter questions and critical thinking activities. This new edition will contribute to creating a genetically literate student population that understands basic biological research, understands elements of the personal and health implications of genetics, and participates effectively in public policy issues involving genetic information . Includes topical material on forensics, disease studies, and the human genome project to engage non-specialist students Full, 4-color illustration program enhances and reinforces key concepts and themes Uniform organization of chapters includes interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers

Understanding the Human Genome Project

  • Filename: understanding-the-human-genome-project.
  • ISBN: 0805367748
  • Release Date: 2002
  • Number of pages: 36
  • Author: Michael Angelo Palladino
  • Publisher: Benjamin-Cummings Publishing Company

Completion of the Human Genome Project is just the tip of the iceberg in our understanding of human genetics. How can information gathered during the Human Genome Project be used? This brief booklet explains in accessible language what readers need to understand about the Human Genome Project, including the background, findings, and social and ethical implications. The author, Michael Palladino, also includes relevant Web resources and exercises for readers.


  • Filename: genomics.
  • ISBN: 9780471461869
  • Release Date: 2004-01-06
  • Number of pages: 596
  • Author: Charles R. Cantor
  • Publisher: John Wiley & Sons

A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features: Topical organization within chapters for easy reference A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids Informed predictions for the future of DNA sequencing

The Gene Wars

  • Filename: the-gene-wars.
  • ISBN: 0393313999
  • Release Date: 1996-01
  • Number of pages: 416
  • Author: Robert Cook-Deegan
  • Publisher: W. W. Norton & Company

The Human Genome Project, the most ambitious biological research program ever undertaken, was born in controversy. Heralded by its more enthusiastic proponents as a quest for the 'Holy Grail of biology' - and the key, ultimately, to the treatment of a variety of hereditary diseases - it has as its initial goal the mapping of all the genes in the entire three-billion-letter genetic code embodied in the DNA of a typical human cell. A major factor in the counterarguments of its opponents: its projected cost, estimated to run into the billions of dollars, spread over 10-20 years. In this firsthand account of the protracted struggle to launch the genome project, a close observer of that process - and sometime participant in it - unravels the tangled scientific and political threads of the story, relying on primary documents gathered even as events unfolded, supplemented by interviews with all the main actors - including the controversial first head of the National Institutes of Health genome effort, Nobel laureate James D. Watson. The result is an absorbing case study in the politics of modern science - focused in this case on a project with far-reaching medical and social implications.

Investigating the Human Genome

  • Filename: investigating-the-human-genome.
  • ISBN: 0132172844
  • Release Date: 2011-06-08
  • Number of pages: 256
  • Author: Moyra Smith
  • Publisher: FT Press

Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome. This book addresses into a wide spectrum of topics associated with human genetics and genomics, including: Human origins; migrations and human population diversity gained though genomic analyses. The complexities of psychiatric diseases that are influenced by genetics. The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS. Key aspects of protein misfolding. Gene-environment interactions in DNA damage and repair and DNA instability. Micro RNAs and mRNA translation. Epigenetics. New functions for old enzymes in cancer.

Mapping and Sequencing the Human Genome

  • Filename: mapping-and-sequencing-the-human-genome.
  • ISBN: 9780309535007
  • Release Date: 1988-01-15
  • Number of pages: 106
  • Author: Committee on Mapping and Sequencing the Human Genome
  • Publisher: National Academies Press

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

A Guide to the Human Genome Project

  • Filename: a-guide-to-the-human-genome-project.
  • ISBN: 0941901106
  • Release Date: 1993
  • Number of pages: 40
  • Author: Susan L. Speaker
  • Publisher: Chemical Heritage Foundation

This simple, concise introduction to the HGP for the general reader explores the origins of the genome project and reactions in the scientific community; important technologies and techniques; institutions connected with the HGP, including designated genome centers, important suppliers of resources, and corporations; systems of communication; and ethical, legal, and social issues. A publication of the Biomolecular Sciences Initiative of CHF's Beckman Center for the History of Chemistry.

The Human Genome

  • Filename: the-human-genome.
  • ISBN: 0123334608
  • Release Date: 1999
  • Number of pages: 415
  • Author: R. Scott Hawley
  • Publisher: Academic Press

Offering a concise treatment of topics in human genetics, this text begins with coverage of the fundamental concepts of genetics and heredity then illustrates these concepts as they relate to the development of human sexual differentiation and sexuality. The book presents the role of the X and Y chromosomes, the role of hormone-controlled differential gene expression in sex determination, and the role of genetics in sexual orientation and sex-role development.

The Human Genome Project

  • Filename: the-human-genome-project.
  • ISBN: 0823936716
  • Release Date: 2002-07
  • Number of pages: 64
  • Author: James Toriello
  • Publisher: The Rosen Publishing Group

Describes potential uses for the ten-year, multimillion dollar Human Genome Project and its process of gene mapping; includes web citation for an interactive map of chromosomes.

The Human Genome

  • Filename: the-human-genome.
  • ISBN: 9781448808564
  • Release Date: 2010-08-15
  • Number of pages: 80
  • Author: Bridget Heos
  • Publisher: The Rosen Publishing Group

Presents an introduction to genetics, discussing genes, chromosomes, probability, DNA, mutation, and the Human Genome Project.

Life Script

  • Filename: life-script.
  • ISBN: 9780743217392
  • Release Date: 2002-03-02
  • Number of pages: 208
  • Author: Nicholas Wade
  • Publisher: Simon and Schuster

With the decoding of the human genome, researchers can now read the script in which evolution has written the program for the design and operation of the human body. A new generation of medical treatments is at hand. Researchers are developing therapies so powerful that there is now no evident obstacle to the ancient goal of conquering most major diseases. Nicholas Wade has covered the sequencing of the genome, as well as other health and science stories, for The New York Times, in the course of which he has interviewed many of the principal researchers in the field. In this book he describes what the genome means for the health of present and future generations. Someday soon physicians will have access to DNA chips that, from a drop of blood, will screen a person's genes for all the diseases to which he or she may be genetically vulnerable. From full knowledge of the instruction manual of the human body, provided by the genome, pharmaceutical companies hope to develop a new generation of sophisticated drugs; one of the first genome-derived drugs is already undergoing clinical trials. Another vital tool will be regenerative medicine, a new kind of therapy in which new organs and tissues will be grown from a patient's own cells to replace those that are old or diseased. With the help of DNA chips, medical researchers will soon be able to diagnose diseases such as cancer much more precisely and to tailor specific treatments for each patient. Individualized medicine will also become an important part of the pharmaceutical world. Many drugs will be prescribed based on information from DNA chips that identify which of a range of drugs is best for each patient, as well as which drugs are likely to cause side effects. The medicine of the post-genomic era will be customized for a patient's genetic make-up, providing treatments based on a precise understanding of the mechanism of disease. Life Script describes a future in which good health, even perfect health, may become the standard for everyone -- at every age.

The Human Genome Project and the Future of Health Care

  • Filename: the-human-genome-project-and-the-future-of-health-care.
  • ISBN: 0253113253
  • Release Date: 1996-12-22
  • Number of pages: 264
  • Author: Thomas H. Murray
  • Publisher: Indiana University Press

"The volume deserves our serious attention. The authors have provided us an invaluable primer about the HGP and its implications for the future of American health care." -- Jurimetrics "This book does make a real contribution... in explaining why the genetics revolution holds so much promise and why it is so difficult to bring that promise to fruition." -- The Journal of Legal Medicine "... marked by a forward-looking, analytically and empirically grounded thematic coherence. The editors' carefully crafted template and contributions successfully focus and organize the material." -- Annals of Internal Medicine "Excellent" -- Canadian Medical Association Journal "The editors have done a very good job integrating the contents into a very useful and readable information source." -- Choice "... this highly focused book is a well-written, thoughtful, and insightful consideration of the HGP and is valuable reading for anyone concerned with the future of our country's medical infrastructure." -- Science Books & Films (**Highly recommended) "A distinguished group of scientists, lawyers, and scholars have written a coherent, readable account of the legal, medical, ethical, and policy issues many (if not all) of us will be wrestling with on both a personal and a public level, as a result of current genetic research." -- Library Journal "Each of the contributors is a distinguished authority on the topic. Ethicists, especially, will find well-developed presentation of issues, with exposition of the differing ethical assumptions in tension in the society debate." -- Doody's Health Sciences Book Review Home Page How will the science of gene mapping and gene manipulation affect health care? Leading scholars explore the clinical, ethical, legal, and policy implications of the Human Genome Project for the forms of health care, who delivers it, who receives it, and who pays for it.

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