The Handbook of Biomarkers

  • Filename: the-handbook-of-biomarkers.
  • ISBN: 1607616858
  • Release Date: 2010-02-06
  • Number of pages: 492
  • Author: Kewal K. Jain
  • Publisher: Springer Science & Business Media



Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Biomarkers in Drug Development

  • Filename: biomarkers-in-drug-development.
  • ISBN: 9781118210420
  • Release Date: 2011-09-20
  • Number of pages: 784
  • Author: Michael R. Bleavins
  • Publisher: John Wiley & Sons



Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes

  • Filename: the-handbook-of-neuropsychiatric-biomarkers-endophenotypes-and-genes.
  • ISBN: 9781402098383
  • Release Date: 2009-04-21
  • Number of pages: 213
  • Author: Michael S. Ritsner
  • Publisher: Springer Science & Business Media



Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

International Handbook of Adult Mortality

  • Filename: international-handbook-of-adult-mortality.
  • ISBN: 9048199964
  • Release Date: 2011-02-18
  • Number of pages: 626
  • Author: Richard G. Rogers
  • Publisher: Springer Science & Business Media



This handbook presents a comprehensive and up-to-date overview of unprecedented substantive, theoretical, methodological, and statistical developments and insights, and an in-depth examination of trends and patterns, in adult mortality around the world. With over two dozen chapters and more than 50 authors, this volume draws from top international mortality experts to provide one of the best overviews of life expectancy extant. The book documents remarkable gains in life expectancy, which stand out as one of the most important accomplishments of the twentieth century. Individuals in more developed countries can expect to live longer now than ever before, especially the Japanese who enjoy record-setting life expectancies. The book also explores unfortunate declines in life expectancy in selected countries brought on by such factors as infectious diseases; accidents, suicides, and homicides; and political and economic conflict and turmoil. This book synthesizes the wealth of mortality information available, clearly articulates the central findings to-date, identifies the most appropriate datasets and methods currently available, illuminates the central research questions, and develops an agenda to address these research questions. The authors carefully examine central factors related to mortality, including health behaviors, socioeconomic status, social relations, biomarkers, and genetic factors. The book will prove especially relevant to researchers, students, and policy makers within social and health sciences who want to better understand international trends and patterns in adult mortality.

The Handbook of Nanomedicine

  • Filename: the-handbook-of-nanomedicine.
  • ISBN: 1603273190
  • Release Date: 2008-02-24
  • Number of pages: 404
  • Author: Kewal K. Jain
  • Publisher: Springer Science & Business Media



This handbook covers the broad scope of nanomedicine. Starting with the basics, the subject is developed to potential clinical applications, many of which are still at an experimental stage. The book features extensive coverage of nanodiagnostics and nanopharmaceuticals, which are two important components of nanomedicine. Written by a physician-scientist author who blends his clinical experience and scientific expertise in new technologies, this book provides a definitive account of nanomedicine. It offers more up-to-date and comprehensive coverage of nanomedicine than any other comparable work.

Handbook of Toxicology of Chemical Warfare Agents

  • Filename: handbook-of-toxicology-of-chemical-warfare-agents.
  • ISBN: 0080922732
  • Release Date: 2009-04-02
  • Number of pages: 1168
  • Author: Ramesh C. Gupta
  • Publisher: Academic Press



This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book. This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market. Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time. The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book. Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with.

Handbook of Practical Immunohistochemistry

  • Filename: handbook-of-practical-immunohistochemistry.
  • ISBN: 9781493915781
  • Release Date: 2015-02-21
  • Number of pages: 764
  • Author: Fan Lin
  • Publisher: Springer



In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Handbook of Hair in Health and Disease

  • Filename: handbook-of-hair-in-health-and-disease.
  • ISBN: 9789086861743
  • Release Date: 2011-11-01
  • Number of pages: 493
  • Author: Victor R. Preedy
  • Publisher: Wageningen Academic Pub



Hair is a major component of the body's tissue system that contributes to the individual's make up and confers a large degree of personal identity. Apart from its visible façade, hair also has a functional role. It has an unique structure and complex molecular development. The very nature of hair makes it a suitable marker for the prognosis of disease. Hair can also be used to screen for toxins and changes in the diet. However, there are currently no suitable publications available that describe hair in a rational scientific context. This handbook provides an academic approach to hair in health and disease. Divided into five sections the Handbook of Hair in Health and Disease provides an insight into hair growth and loss, molecular and cellular biology of hair, dietary toxicity and pathological history, diseases and treatments of hair, as well as shampoos and conditioners. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that will give a clear overview of the subjects treated in each chapter.The Handbook of Hair in Health and Disease will be essential to a variety of users, such as trichologists, doctors and nurses and all those interested or working within the area of hair health. This includes nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.

Handbook on the Toxicology of Metals

  • Filename: handbook-on-the-toxicology-of-metals.
  • ISBN: 9780123973399
  • Release Date: 2014-08-07
  • Number of pages: 1542
  • Author: Gunnar F. Nordberg
  • Publisher: Academic Press



Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium

Handbook of Diet Nutrition and the Skin

  • Filename: handbook-of-diet-nutrition-and-the-skin.
  • ISBN: 9789086861750
  • Release Date: 2012
  • Number of pages: 487
  • Author: Victor R. Preedy
  • Publisher: Wageningen Academic Pub



Skin diseases can affect up to 80% of the population. These diseases range from blemishes to frank cancerous growth. Included in this are psoriasis and acne which affect literally millions of people. Some diseases such as skin cancer can be life threatening. Other diseases can however, lead to permanent scaring. Moreover, novel nutritional components have been used experimentally to treat skin conditions and their clinical application await confirmation. It is thus up to health care professionals to present new knowledge in order to provide advice or treatments for these skin problems. Studies have clearly shown that optimal diet and nutrition can prevent skin disease. Moreover, nutritional components can also be used for therapeutic treatments. This handbook provides, in a single volume, comprehensive coverage of skin, diet and nutrition in its broadest sense. The Handbook of diet, nutrition and the skin consists of sections on general aspects of skin, nutrition and diet, micronutrients, nutraceuticals, cancer and specific skin conditions. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that are designed to abstract each chapter in take home messages. This handbook will be of interest to a wide range of readers, such as dermatologists, doctors, nurses and those interested in, or working within the area of skin health. This will of course also include nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.

Biomarkers in Toxicology

  • Filename: biomarkers-in-toxicology.
  • ISBN: 9780124046498
  • Release Date: 2014-01-25
  • Number of pages: 1152
  • Author: Ramesh C. Gupta
  • Publisher: Academic Press



Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

Oxford Handbook of Oncology

  • Filename: oxford-handbook-of-oncology.
  • ISBN: 9780199563135
  • Release Date: 2010-05-20
  • Number of pages: 845
  • Author: Jim Cassidy
  • Publisher: Oxford University Press



Oxford Handbook of Oncology a practical guide to clinical consultations in oncology. It details new approaches to diagnosis, treatment and the principles of palliative care.

The Handbook of Metabonomics and Metabolomics

  • Filename: the-handbook-of-metabonomics-and-metabolomics.
  • ISBN: 0080468004
  • Release Date: 2011-08-11
  • Number of pages: 572
  • Author: John C. Lindon
  • Publisher: Elsevier



Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Handbook of Therapeutic Biomarkers in Cancer

  • Filename: handbook-of-therapeutic-biomarkers-in-cancer.
  • ISBN: 9789814364669
  • Release Date: 2013-06-21
  • Number of pages: 518
  • Author: Sherry X. Yang
  • Publisher: CRC Press



In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.

The Handbook of Medicinal Chemistry

  • Filename: the-handbook-of-medicinal-chemistry.
  • ISBN: 9781849736251
  • Release Date: 2014-12-09
  • Number of pages: 753
  • Author: Andrew Davis
  • Publisher: Royal Society of Chemistry



Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.

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