The Bacteriophages

  • Filename: the-bacteriophages.
  • ISBN: 0198033850
  • Release Date: 2005-12-15
  • Number of pages: 768
  • Author: . Stephen T. Abedon
  • Publisher: Oxford University Press



This authoritative, timely, and comprehensively referenced compendium on the bacteriophages explores current views of how viruses infect bacteria. In combination with classical phage molecular genetics, new structural, genomic, and single-molecule technologies have rendered an explosion in our knowledge of phages. Bacteriophages, the most abundant and genetically diverse type of organism in the biosphere, were discovered at the beginning of the 20th century and enjoyed decades of used as anti-bacterial agents before being eclipsed by the antibiotic era. Since 1988, phages have come back into the spotlight as major factors in pathogenesis, bacterial evolution, and ecology. This book reveals their compelling elegence of function and their almost inconceivable diversity. Much of the founding work in molecular biology and structural biology was done on bacteriophages. These are widely used in molecular biology research and in biotechnology, as probes and markers, and in the popular method of assesing gene expression.

The Bacteriophages

  • Filename: the-bacteriophages.
  • ISBN: 9781468454246
  • Release Date: 2012-12-06
  • Number of pages: 614
  • Author: Richard Calendar
  • Publisher: Springer Science & Business Media



It has been 10 years since Plenum included a series of reviews on bacte riophages, in Comprehensive Virology. Chapters in that series contained physical-genetic maps but very little DNA sequence information. Now the complete DNA sequence is known for some phages, and the se quences for others will soon follow. During the past 10 years two phages have come into common use as reagents: A phage for cloning single copies of genes, and Ml3 for cloning and DNA sequencing by the dideoxy termi nation method. Also during that period the use of alternative sigma fac tors by RNA polymerase has become established for SPOl and T4. This seems to be a widely used mechanism in bacteria, since it has been implicated in sporulation, heat shock response, and regulation of nitro gen metabolism. The control of transcription by the binding of A phage CII protein to the -35 region of the promoter is a recent finding, and it is not known how widespread this mechanism may be. This rapid progress made me eager to solicit a new series of reviews. These contributions are of two types. Each of the first type deals with an issue that is exemplified by many kinds of phages; chapters of this type should be useful in teaching advanced courses. Chapters of the second type provide comprehensive pictures of individual phage families and should provide valuable information for use in planning experiments.

Bacteriophages and Biofilms

  • Filename: bacteriophages-and-biofilms.
  • ISBN: 1617615889
  • Release Date: 2011
  • Number of pages: 138
  • Author: Stephen T. Abedon
  • Publisher: Nova Biomedical Books



Bacteriophages (phages) are the viruses of bacteria and biofilms that represent a frequent niche for bacteria, where they are embedded in extensive extracellular polymeric substances (EPS) and can be structured into complex microcolonies. As a consequence of the resulting spatial structure and heterogeneity, phage-bacterial interactions within biofilms can be more complicated than those between phages and planktonic bacteria. This book presents and discusses research which provides a better understanding of the biology of phages interacting with biofilms.

Bacteriophages in Health and Disease

  • Filename: bacteriophages-in-health-and-disease.
  • ISBN: 1845939859
  • Release Date: 2012
  • Number of pages: 296
  • Author: P. Hyman
  • Publisher: CABI



This book, Bacteriophages in health and disease, is an effort to provide an introduction to the breadth of roles that phages play or can play in our everyday lives. To capture this variety of phage roles in human conditions, both natural and applied, the book is divided into three parts. A brief introduction to various concepts and terminology associated with phages is provided in chapter 1. Part I (chapters 2-6) considers the role of phages in the natural state. That is, where phages are, how they contribute directly to disease, the underlying mechanism by which phages do this, and how they can contribute indirectly to disease, that is, to pathogen evolution. Part II (chapters 7-11) considers various phage-based technologies other than the use of whole phages to combat bacterial infections (i.e. besides phage therapy). This includes in particular the use of both modified and 'disembodied' phage parts. Phages thus can serve as carriers and delivery vehicles of DNA and also of other chemicals, including serving as vectors for either gene therapy or DNA vaccines. Part III (chapters 12-17) covers phage-based antibacterial strategies. It includes chapters on: phage translocation, safety and immunomodulation; phage therapy of wounds and related purulent infections; phage therapy of non-wound infections; phage-based enzybiotics; and phage-based control of bacterial pathogens in food. The final chapter of this book is targeted to would-be phage therapy experimentalists, one that considers, in light of phage properties, how phage therapy protocols may be developed in terms of the use of animal models of bacterial disease.

Bacteriophages

  • Filename: bacteriophages.
  • ISBN: 0203491750
  • Release Date: 2004-12-28
  • Number of pages: 528
  • Author: Elizabeth Kutter
  • Publisher: CRC Press



In response to the emergence of pathogenic bacteria that cannot be treated with current antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight multidrug-resistant bacteria. Bacteriophages: Biology and Applications provides unparalleled, comprehensive information on bacteriophages and their applications, such as phage therapy. It offers techniques, media, and methodology involved in isolating and working with therapeutic phages. Photographs, line drawings, and electron micrographs of phages are also included. With its broad approach, this book is a useful reference for microbiologists, hematologists, and infectious disease researchers.

Bacteriophage Ecology

  • Filename: bacteriophage-ecology.
  • ISBN: 9781139471947
  • Release Date: 2008-05-01
  • Number of pages:
  • Author: Stephen T. Abedon
  • Publisher: Cambridge University Press



Bacteriophages, or phages, are viruses that infect bacteria and are believed to be the most abundant and genetically diverse organisms on Earth. As such, their ecology is vast both in quantitative and qualitative terms. Their abundance makes an understanding of phage ecology increasingly relevant to bacterial ecosystem ecology, bacterial genomics and bacterial pathology. Abedon provides the first text on phage ecology for almost 20 years. Written by leading experts, synthesizing the three key approaches to studying phage ecology, namely studying them in natural environments (in situ), experimentally in the lab, or theoretically using mathematical or computer models. With strong emphasis on microbial population biology and distilling cutting-edge research into basic principles, this book will complement other currently available volumes. It will therefore serve as an essential resource for graduate students and researchers, particularly those with an interest in phage ecology and evolutionary biology.

Bacteriophage

  • Filename: bacteriophage.
  • ISBN: 9781904455141
  • Release Date: 2007
  • Number of pages: 343
  • Author: Stephen Mc Grath
  • Publisher: Horizon Scientific Press



Bacteriophages (viruses that infect bacteria) are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host - for example, converting a non-pathogenic strain into a pathogen - and they play a key role in regulating bacterial populations in all sorts of environments. The phage-bacterium relationship varies enormously, from the simple predator-prey model to a complex, almost symbiotic relationship that promotes the survival and evolutionary success of both. While infection of bacteria used in the fermentation industry can be very problematic and result in financial losses, in other scenarios, phage infection of bacteria can be exploited for industrial and/or medical applications. Interest in phage and phage gene products as potential therapeutic agents is increasing rapidly and is likely to have a profound impact on the pharmaceutical industry and biotechnology in general over the coming years. One potential application is the use of phage to combat the growing menace of antibiotic-resistant infections. Written by eminent international researchers actively involved in the disparate areas of bacteriophage research, this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current, most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype, and much more. The book will be essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology, and pharmaceutical companies, as well as in the food industry.

Bacteriophages

  • Filename: bacteriophages.
  • ISBN: UOM:39015075645476
  • Release Date: 2009
  • Number of pages: 308
  • Author: Martha R. J. Clokie
  • Publisher: Humana PressInc



Ranging from the evolution of pathogenicity to oceanic carbon cycling, the many and varied roles that bacteriophages play in microbial ecology and evolution have inspired increased interest within the scientific community. This book pulls together the vast body of knowledge and expertise from top international bacteriophage researchers to provide both classical and state-of-the-art molecular techniques. With its well-organized modular design, Volume 1 examines a multitude of topics, including the isolation of phages, morphological and molecular characterization, and interaction with bacteria. Volume 2 examines a multitude of topics, including the bacteriophage genomics, metagenomics, transcriptomics, and proteomics, along with applied bacteriophage biology. Written in the highly successful Methods in Molecular Biology series format, chapters consist of brief introductions to the subject, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and a Notes section which details tips on troubleshooting and avoiding known pitfalls.

Bacteriophage Applications Historical Perspective and Future Potential

  • Filename: bacteriophage-applications-historical-perspective-and-future-potential.
  • ISBN: 9783319457918
  • Release Date: 2016-10-04
  • Number of pages: 82
  • Author: Jessica Nicastro
  • Publisher: Springer



This book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries. Since the discovery of phages and the advent of phage display systems, considerable attention has been focused on the development of novel therapeutic and industrial applications. Recent studies combine the genomic flexibility of phages with phage display systems in order to generate modified phages for targeted delivery.

Bacterial and Bacteriophage Genetics

  • Filename: bacterial-and-bacteriophage-genetics.
  • ISBN: 9780387314891
  • Release Date: 2006-04-04
  • Number of pages: 578
  • Author: Edward A. Birge
  • Publisher: Springer Science & Business Media



Genetic investigations and manipulations of bacteria and bacteriophage have made vital contributions to our basic understanding of living cells and to the development of molecular biology and biotechnology. This volume is a survey of the genetics of bacteria and their viruses, and it provides students with a comprehensive introduction to this rapidly changing subject. The book is written for upper level undergraduates and beginning graduate students, particularly those who have had an introductory genetics course. The fifth edition has been extensively revised to reflect recent advances in the field. The book now has a reader-friendly look, with end-of-chapter questions, "Thinking Ahead" and "Applications" boxes to challenge students’ comprehension and insights. A complete glossary of commonly used terms has been revised and expanded.

Phage Therapy

  • Filename: phage-therapy.
  • ISBN: 1908230401
  • Release Date: 2014-04
  • Number of pages: 406
  • Author: Jan Borysowski
  • Publisher:



The emergence of bacteria resistant to multiple antibiotics has become a serious threat to public health and is considered one of the greatest challenges for contemporary medicine. Phage therapy - the use of bacteriophages as anti-bacterial agents - may offer an alternative treatment for bacterial infections. Phages have many potential applications in human medicine, as well as in dentistry, veterinary science, agriculture, and food protection. Written by internationally recognized experts from leading centers involved in phage research and phage therapy, this book provides comprehensive coverage of the topic with a focus on current research and emerging applications. The book opens with chapters covering the general characteristics of bacteriophages and the basic concepts of phage therapy. Further topics include: the pharmacology of phage therapy * bacterial resistance * non-bactericidal effects of phages * main applications of bacteriophages in clinical medicine * plant pathosystems * animal production * food protection * biofilm control * regulatory and intellectual property aspects of phage therapy. Although the book focuses on applications of virulent bacteriophages, it also discusses genetically-engineered phages, phages as delivery vehicles for other antimicrobials, as well as phage lysins. It will be an essential reference for anyone interested in phage therapy, antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol, and biodetection. [Subject: Molecular Biology, Life Science, Medicine]

A Planet of Viruses

  • Filename: a-planet-of-viruses.
  • ISBN: 9780226983363
  • Release Date: 2012-04-30
  • Number of pages: 109
  • Author: Carl Zimmer
  • Publisher: University of Chicago Press



Explores the hidden world of viruses, explaining how they profoundly affect human lives and updating the reader in current virus-related issues, such has the frenetic evolution of the HIV virus, which could pose greater dangers in the future. By the author of Parasite Rex.

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