RNA DNA and Cancer

  • Filename: rna-dna-and-cancer.
  • ISBN: 9783319222790
  • Release Date: 2016-04-01
  • Number of pages: 815
  • Author: Joseph G. Sinkovics
  • Publisher: Springer



In this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that “malignantly transformed” human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe. This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells.

DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases

  • Filename: dna-and-rna-cleavers-and-chemotherapy-of-cancer-and-viral-diseases.
  • ISBN: UOM:39015040647136
  • Release Date: 1996-01-01
  • Number of pages: 372
  • Author: Bernard Meunier
  • Publisher: Kluwer Academic Pub



Recently, there has been an increase of interest in the discovery and design of drugs that cleave DNA and RNA with sequence specificity. This class of compounds can be used as therapeutic agents, especially in the treatment of cancer and viral diseases. Novel mechanisms have also been discovered, allowing such agents to be used as tools in the study of the structure and function of nucleic acids. The major advances have been achieved with enediyne antibiotics and their synthetic analogues, bleomycin-metal complexes, metal-drug complexes, ribozymes and their mimics, and antisense and antigene oligonucleotides. This study discusses DNA cleavage by enediyne molecules, the mechanism of action of bleomycin, the paradigm of DNA cleavers site-specific DNA and RNA cleavage and its mechanism, RNA cleavage by RNase H, RNA hydrolysis by ribozymes and metal complexes, and redox regulation of the human immunodeficiency virus.

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

  • Filename: apoptotic-pathways-as-targets-for-novel-therapies-in-cancer-and-other-diseases.
  • ISBN: 9780387236957
  • Release Date: 2006-06-20
  • Number of pages: 395
  • Author: Marek Los
  • Publisher: Springer Science & Business Media



As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Atlas of the Prostate

  • Filename: atlas-of-the-prostate.
  • ISBN: 9781461565055
  • Release Date: 2012-12-06
  • Number of pages: 207
  • Author: Reginald Bruskewitz
  • Publisher: Springer Science & Business Media



generated a plethora of well-controlled randomized trials to This second edition of the Atlas of the Prostate summarizes the current evaluation and treatment of prostatic diseases. Diseases of investigate nearly every facet of management. The individuals who conducted many of these clinical trials, which so precisely the prostate invariably affect men as they age into their sixth decade of life and beyond, and physicians who provide care for inform us as to the efficacy of these treatments, are in many older men invariably devote a greater portion of their clinical instances authors in this Atlas. attention to the prostate. This Atlas conveys important information Prostate cancer management has likewise been an area of inno to practicing clinicians using figures, images, tables, and algo vation and change in practice patterns. The emergence of rithms in a most artful rendition. The contributors are practicing brachytherapy with seed implantation of the prostate, new strate clinicians, and they have produced a clear and concise review of gies for androgen manipulation of advanced prostatic cancer, and prostatic diseases. The format emphasizes figures and tables over further attempts to identify effective chemotherapeutic agents are some of the advances in prostate cancer management seen in the text to accurately and quickly provide the pertinent thoughts regarding prostatic disease management for the busy clinician. past one to two decades.

Molecular Pathology of Breast Cancer

  • Filename: molecular-pathology-of-breast-cancer.
  • ISBN: 9783319417615
  • Release Date: 2016-12-25
  • Number of pages: 428
  • Author: Sunil Badve
  • Publisher: Springer



The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

The Biology of Cancer

  • Filename: the-biology-of-cancer.
  • ISBN: 0470518170
  • Release Date: 2007-09-27
  • Number of pages: 216
  • Author: Janice Ann Gabriel
  • Publisher: John Wiley & Sons



Advances in research and the treatment of cancer mean that more patients and their carers are asking healthcare professionals about the latest treatments and how they may be of benefit. It is essential that staff working with cancer patients understand fully how these new treatments work in order to disseminate timely and appropriate information to patients. The application of biology to the delivery of cancer care is playing an ever-increasing role in the management of these diseases. The Biology of Cancer: Second Edition provides details of the most recent developments in cancer care and is divided into three sections: Understanding Cancer – examines predisposing factors to developing cancer, diagnosis and its implications on the individual and society. The Science of Cancer – a closer look at the cell, genetics, the immune system, tumour markers and monoclonal antibodies. Research and Treatment – exploring translational oncology, applying research methodology to cancer research and research ethics relating to cancer. This fully updated edition also looks at evidence-based research that can be translated directly to patient care and gives details recent developments. Written by experienced, practicing healthcare professionals, The Biology of Cancer: Second Edition can easily be applied to patient care. It is an informative text for students, newly qualified nurses and practising oncology/palliative care nurses.

Cancer Diagnostics

  • Filename: cancer-diagnostics.
  • ISBN: 9781592597918
  • Release Date: 2004-07-16
  • Number of pages: 508
  • Author: Robert M. Nakamura
  • Publisher: Springer Science & Business Media



Cancer Management in Man

  • Filename: cancer-management-in-man.
  • ISBN: 9789400910959
  • Release Date: 2012-12-06
  • Number of pages: 248
  • Author: Paul V. Woolley
  • Publisher: Springer Science & Business Media



This volume, the last in this series on cancer growth and Moreover, the current status of plant-derived vinca alka progression, is a companion volume to Volume IX and loids and non-alkaloid natural products is summarized. further explores established and novel approaches for the Advances in hyperthermia and additional approaches for therapy of patients with malignant neoplasms. The stra the therapy of malignancies are also presented. tegies reflected in these volumes are direct extrapolations The volume continues with chapters on bone marrow from the basic science of cancer biology, growth and pro transplantation as well as hematologic and nutritional sup gression described in earlier volumes of this series. Some port for the cancer patient. Blood pressure in the cancer approaches are directed towards the eradication or modifi patient, therapy for nausea and vomiting as well as pain are cation of the properties of heterogeneous malignant tumor discussed. The last chapter is devoted to the problems of the cells at various stages of tumor progression, while other terminally ill, including evaluations of the burden relatives approaches are directed towards modification of the host and friends of the cancer patient have to bear. antitumor defense systems, e. g. , enhancement of host anti It is clear that important advances in the basic science of tumor immune reactivity.

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