- Filename: peptides.
- ISBN: UOM:39015015994315
- Release Date: 1975
- Number of pages: 1053
- Author: Roderich Walter
- Publisher: Ann Arbor Science Publishers
These proceedings of the Twelfth American Peptide Symposium include 363 articles which were selected for publication on the basis of originality, timeliness and scientific significance. This volume includes contributions on ppetide hormones, neuropeptides, lipid-interactive peptides, peptide and protein conformation, de novo design, structure-activity relationships, synthetic methods, large-scale peptide synthesis, viruses and vaccines, peptide mimetics, peptide inhibitors, immunology and new biologically active peptides.
From the first and second sessions on peptide hormones and neuropeptides, one can gain an appreciation of the role to be fulfilled by peptide hormone analogs in medicine. There does not seem to be a single bioactive peptide family for which a therapeutic role is not envisioned at this time. Most interesting is the fact that short analogs as well as cyclic analogs, with structures that are often quite dissimilar from that of the parent native hormone, are being considered as potential drugs. Increased potency and duration of action generally result from these structural modifications. In the third session, emphasis is put on one's recognition of the ever-growing role of lipid membranes in modulating biological expression. Refinement of one's understanding of the bioactive conformation of a peptide is paramount for allowing rational design. Only sophisticated techniques such as NMR in different solvent systems, coupled to molecular modeling in different environments, and X-ray crystallography will yield the information needed to gain an appreciation of the bioactive conformation of a peptide.
This mini-encyclopedia contains more than 1,500 alphabetical entries from the entire field of peptide science in one handy volume, as well as the technical terms, acronyms and concepts used in peptide chemistry. It also features the complete sequence of more than 800 peptides, numerous illustrations and numerous cross-references. Areas covered include: - biological peptides and small proteins - peptide hormones - pharmaceutical peptides - peptide antibiotics - peptide inhibitors - peptide reagents - peptide tags - structural classes - synthesis and purification - analytical methods - proteomics and peptidomics. Condensed yet accessible, only essential information is displayed, extensively linked via references to the recent scientific literature for further study.
This unique reference book contains 372 articles selected from 762 plenary lectures, workshops and poster presentations made during the Thirteenth American Peptide Symposium held in Edmonton, Alberta, Canada. The book opens with Nobel Laureate Dr. Bruce Merrifield's `Remarks on Peptide Chemistry' which focus on past scientists and their contributions of peptide chemistry in all aspects of biology, and Dr. Victor Hruby's Pierce Award Lecture on designing peptides, pseudopeptides and peptidomimetics to understand the relationship between structure and biology activity. The contributions are grouped into 14 sections: Synthetic and Analytical Methods Peptide Mimetics Glycopeptides/Lipopeptides Peptide Hormones/Neuropeptides Peptide Inhibitors/Peptide-Receptor Interactions Peptide Vaccines and Immunology Conformational Analysis Peptide Pharmaceuticals/Diagnostics and Peptide Delivery Computational Biochemistry Peptide Macromolecular Interactions Peptide Libraries De novo Design of Peptides and Proteins; and three Workshops: Approaches and Advances in Peptide Synthesis, Purification and Analysis An Introduction to NMR Spectroscopy of Peptides An Introduction to Energy Minimization, Molecular Dynamics, Molecular Modelling and Conformational Analysis of Peptides. This 1200 page compendium of current research from both academic and industrial laboratories demonstrates the exponential growth of the use of peptides in the diverse fields of medical science.
The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.
Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging. The second edition of Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.
The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides. The approximately one thousand members of the Society come from North America and from more than thirty other countries throughout the world. Establishment of the APS was a result of the rapid worldwide growth that has occurred in peptide-related research, and of the increasing interaction of peptide scientists with virtually all fields of science. Peptides for Youth: The Proceedings of the the 20th American Peptide Symposium will highlight many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. The 20th American Peptide Symposium will take place June 26 - 30, 2007 in Montreal, Canada.
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. Coverage includes: * The history of peptide chemistry * Amide formation, deprotection, and disulfide formation in peptide synthesis * Solid-phase peptide synthesis * a-helix formation by peptides in water * Stability and dynamics of peptide conformation * An overview of structure-function studies of peptide hormones * Neuropeptides:peptide and nonpeptide analogs * Reversible inhibitors of serine proteinases * Design of polypeptides * Current capabilities and future possibilities of soluble chemical combinatorial libraries * Epitope mapping with peptides * Synthesis and applications of branched peptides in immunological methods and vaccines
Indispensable reference source for researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia.
Pharmacochemistry Library, Volume 19: Small Peptides: Chemistry, Biology, and Clinical Studies focuses on the processes, reactions, properties, and characteristics of peptides, including analogues and proteases. The publication first takes a look at angiotensin II and bombesin/gastrin-releasing peptide. Topics include conformationally restricted analogues of bombesin, non-peptide antagonists of angiotensin II, receptor subtypes of angiotensin II, and bombesin/GRP antagonists and cancer. The text then elaborates on bradykinin, cholecystokinin, and enkephalin analogues. The manuscript examines luteinizing hormone releasing hormone and somatostatin. Topics include enzymic degradation of somatostatin and analogues, clinical applications of somatostatin analogues, and pharmacological and clinical studies with LHRH agonists and antagonists. The formulation of peptides and inhibitors of aspartyl proteases are also mentioned. The book is a valuable source of information for chemists, biologists, and readers interested in small peptides.