Novel Mechanisms of Memory

  • Filename: novel-mechanisms-of-memory.
  • ISBN: 9783319243641
  • Release Date: 2015-12-09
  • Number of pages: 181
  • Author: Karl Peter Giese
  • Publisher: Springer



This book integrates discoveries from recent years to show the diversity of molecular mechanisms that contribute to memory consolidation, reconsolidation, extinction, and forgetting. It provides a special focus on the processes that govern functional and structural plasticity of dendritic spines. In nine chapters, new and important ideas related to learning and memory processes will be presented. Themes discussed include the role of AMPA receptors in memory, two signalling cascades involved in local spine remodelling and memory, the role of extracellular matrix proteins in memory, the regulation of gene expression and protein translation, and mechanisms of retrieval-induced memory modulation and forgetting. We believe that the study of these topics represents a great step toward understanding the complexity of the brain and the processes it governs.

Mechanisms of Memory

  • Filename: mechanisms-of-memory.
  • ISBN: 0080959199
  • Release Date: 2009-09-28
  • Number of pages: 362
  • Author: J. David Sweatt
  • Publisher: Academic Press



This fully revised 2e provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding. More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples

Identification of Novel Mechanisms in the Hypothalamus Linked to Adiposity

  • Filename: identification-of-novel-mechanisms-in-the-hypothalamus-linked-to-adiposity.
  • ISBN: 9780549452416
  • Release Date: 2007
  • Number of pages: 172
  • Author:
  • Publisher: ProQuest



Body composition is a trait regulated by many different genes, giving rise to the severity of the phenotype in a continuous manner. We propose to investigate genetic interactions regulating obesity by focusing on genetic heretibility and genes that interact with Brain-Derived Neurotrophic Factor (BDNF) or thyroid hormone. We have utilized a novel model of obesity, genetically selected chicken lines, because differences in abdominal fat between the lines are based on genotype alone, independent of environmental influences. In order to identify novel gene networks that might give rise to the obese phenotype, hypothalamic gene expression was characterized using microarray technology. Hypothalamic neuronal cell cultures and in vivo manipulations were performed to verify that BDNF interacts with the hypothalamic-pituitary-thyroid axis, while simultaneously identifying novel genes that may interact together or independently of BDNF. A hypothetical model suggesting how BDNF and thyroid hormone reciprocally modulate genes in the hypothalamus already known to contribute to energy regulation was developed.

Recent Advances in the use of Drosophila in Neurobiology and Neurodegeneration

  • Filename: recent-advances-in-the-use-of-drosophila-in-neurobiology-and-neurodegeneration.
  • ISBN: 9780123870193
  • Release Date: 2011-09-07
  • Number of pages: 312
  • Author:
  • Publisher: Academic Press



Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Computational Neuroscience

  • Filename: computational-neuroscience.
  • ISBN: 0444503072
  • Release Date: 1999
  • Number of pages: 1090
  • Author: James M. Bower
  • Publisher: Elsevier



This volume includes papers originally presented at the 7th annual Computational Neuroscience Meeting (CNS'98) held in July of 1998 at the Fess Parker Doubletree Inn in Santa Barbara, California. The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as many different experimental preparations and theoretical approaches. The papers published here range from pure experimental neurobiology, to neuro-ethology, mathematics, physics, and engineering. In all cases the research described is focused on understanding how nervous systems compute. The actual subjects of the research include a highly diverse number of preparations, modeling approaches, and analysis techniques. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

Epigenetic Regulation in the Nervous System

  • Filename: epigenetic-regulation-in-the-nervous-system.
  • ISBN: 9780123944054
  • Release Date: 2012-12-31
  • Number of pages: 374
  • Author: J. David Sweatt
  • Publisher: Academic Press



Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Encyclopedia of Behavioral Neuroscience

  • Filename: encyclopedia-of-behavioral-neuroscience.
  • ISBN: 9780080453965
  • Release Date: 2010-06-03
  • Number of pages: 1816
  • Author:
  • Publisher: Newnes



Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

Invertebrate Learning and Memory

  • Filename: invertebrate-learning-and-memory.
  • ISBN: 9780123982605
  • Release Date: 2013-06-18
  • Number of pages: 600
  • Author: Randolf Menzel
  • Publisher: Academic Press



Understanding how memories are induced and maintained is one of the major outstanding questions in modern neuroscience. This is difficult to address in the mammalian brain due to its enormous complexity, and invertebrates offer major advantages for learning and memory studies because of their relative simplicity. Many important discoveries made in invertebrates have been found to be generally applicable to higher organisms, and the overarching theme of the proposed will be to integrate information from different levels of neural organization to help generate a complete account of learning and memory. Edited by two leaders in the field, Invertebrate Learning and Memory will offer a current and comprehensive review, with chapters authored by experts in each topic. The volume will take a multidisciplinary approach, exploring behavioral, cellular, genetic, molecular, and computational investigations of memory. Coverage will include comparative cognition at the behavioral and mechanistic level, developments in concepts and methodologies that will underlie future advancements, and mechanistic examples from the most important vertebrate systems (nematodes, molluscs, and insects). Neuroscience researchers and graduate students with an interest in the neural control of cognitive behavior will benefit, as will as will those in the field of invertebrate learning. Presents an overview of invertebrate studies at the molecular / cellular / neural levels and correlates findings to mammalian behavioral investigations Linking multidisciplinary approaches allows for full understanding of how molecular changes in neurons and circuits underpin behavioral plasticity Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for comparative learning and memory researchers

The Memory Weaver

  • Filename: the-memory-weaver.
  • ISBN: 9781441228208
  • Release Date: 2015-09-01
  • Number of pages: 352
  • Author: Jane Kirkpatrick
  • Publisher: Revell



Eliza Spalding Warren was just a child when she was taken hostage by the Cayuse Indians during a massacre in 1847. Now the young mother of two children, Eliza faces a different kind of dislocation; her impulsive husband wants them to make a new start in another territory, which will mean leaving her beloved home and her departed mother's grave--and returning to the land of her captivity. Eliza longs to know how her mother, an early missionary to the Nez Perce Indians, dealt with the challenges of life with a sometimes difficult husband and with her daughter's captivity. When Eliza is finally given her mother's diary, she is stunned to find that her own memories are not necessarily the whole story of what happened. Can she lay the dark past to rest and move on? Or will her childhood memories always hold her hostage? Based on true events, The Memory Weaver is New York Times bestselling author Jane Kirkpatrick's latest literary journey into the past, where threads of western landscapes, family, and faith weave a tapestry of hope inside every pioneering woman's heart. Readers will find themselves swept up in this emotional story of the memories that entangle us and the healing that awaits us when we bravely unravel the threads of the past.

Semblance Hypothesis of Memory

  • Filename: semblance-hypothesis-of-memory.
  • ISBN: 9781450256216
  • Release Date: 2010-10-18
  • Number of pages: 116
  • Author: Kunjumon Vadakkan
  • Publisher: iUniverse



The semblance hypothesis explains how associative memory can result from the multidimensional semblance of activity from a specific set of presynaptic terminals at different orders of neurons. The hypothesized basic units are then examined for their feasibility to explain various physiological and pathological conditions of the nervous system, ranging from physiological time-scales of memory retrieval to plausible explanation for long term potentiation (LTP).

Advances in Mechanisms Robotics and Design Education and Research

  • Filename: advances-in-mechanisms-robotics-and-design-education-and-research.
  • ISBN: 9783319003986
  • Release Date: 2013-04-17
  • Number of pages: 400
  • Author: Vijay Kumar
  • Publisher: Springer Science & Business Media



This book contains papers on a wide range of topics in the area of kinematics, mechanisms, robotics, and design, addressing new research advances and innovations in design education. The content is divided into five main categories headed ‘Historical Perspectives’, ‘Kinematics and Mechanisms’, ‘Robotic Systems’, ‘Legged Locomotion’, and ‘Design Engineering Education’. Contributions take the form of survey articles, historical perspectives, commentaries on trends on education or research, original research contributions, and papers on design education. This volume celebrates the achievements of Professor Kenneth Waldron who has made innumerable and invaluable contributions to these fields in the last fifty years. His leadership and his pioneering work have influenced thousands of people in this discipline.

The New Cognitive Neurosciences

  • Filename: the-new-cognitive-neurosciences.
  • ISBN: 0262071959
  • Release Date: 2000
  • Number of pages: 1419
  • Author: Michael S. Gazzaniga
  • Publisher: MIT Press



Winner of the 2002 William James Book Award presented by the Society for General Psychology, Division One of the American Psychological Association. This award is given for the best book which furthers the mission of the Society for General Psychology by bringing together researchers and ideas from the various subfields of neuroscience and psychology. The first edition of The Cognitive Neurosciences helped to define the field. The second edition reflects the many advances that have taken place-particularly in imaging and recording techniques. From the molecular level up to that of human consciousness, the contributions cover one of the most fascinating areas of science—the relationship between the structural and physiological mechanisms of the brain/nervous system and the psychological reality of mind. The majority of the chapters in this edition of The Cognitive Neurosciences are new, and those from the first edition have been completely rewritten and updated. This major reference work is now available online as part of MIT CogNet, The Cognitive and Brain Sciences Community online. Sections and section editors: - Plasticity - Ira B. Black - Development - Pasko Rakic - Sensory Systems - J. Anthony Movshon and Colin Blakemore - Motor - Emilio Bizzi - Attention - Michael I. Posner - Memory - Endel Tulving - Language - Willem J. M. Levelt - Thought and Memory - Edward E. Smith and Stephen M. Kosslyn - Emotion - Joseph E. LeDoux - Evolution - Leda Cosmides and John Tooby - Consciousness - Daniel L. Schacter

Neuronal Mechanisms of Memory Formation

  • Filename: neuronal-mechanisms-of-memory-formation.
  • ISBN: 052101803X
  • Release Date: 2005-09-29
  • Number of pages: 508
  • Author: Christian Hölscher
  • Publisher: Cambridge University Press



Long-term potentiation (LTP) is by far the most dominant model for neuronal changes that might encode memory. LTP is an elegant concept that meets many criteria set up by theoreticians long before the model's discovery, and it also fits anatomical data of learning-dependent synapse changes. Since the discovery of LTP, the question has remained about how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate synaptic changes observed after learning with changes produced by artificial stimulation of neurons. These studies have failed to find a correlation between the two forms of synaptic plasticity. In this book, an international group of neurobiologists and psychologists discuss their latest ideas and data. The results of experiments using electrophysiological techniques in vitro are discussed and compared with the results of in vivo experiments. Learning experiments are also discussed. Theoretical models such as the Hebb theory of synaptic changes during learning are compared to different models that do not predict upregulation of synaptic transmission. A wide approach is taken, and research and models in different brain areas such as the neocortex and the basal brain are discussed.

Mechanisms of Lymphocyte Activation and Immune Regulation XI

  • Filename: mechanisms-of-lymphocyte-activation-and-immune-regulation-xi.
  • ISBN: 9780387465302
  • Release Date: 2007-05-21
  • Number of pages: 198
  • Author: Sudhir Gupta
  • Publisher: Springer Science & Business Media



In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

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