Molecular Biology of Human Cancers

  • Filename: molecular-biology-of-human-cancers.
  • ISBN: 9781402031861
  • Release Date: 2005-12-05
  • Number of pages: 508
  • Author: Wolfgang Schulz
  • Publisher: Springer Science & Business Media



Cancer research is now an interdisciplinary effort requiring a basic knowledge of commonly used terms, facts, issues, and concepts. This interdisciplinary book meets this need, providing an authoritative overview to the field. It presents many of the molecules and mechanisms generally important in human cancers and examines a broad, but exemplary, selection of cancers. In addition, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. This book summarizes the state, pitfalls, and potential of these efforts.

Molecular Carcinogenesis and the Molecular Biology of Human Cancer

  • Filename: molecular-carcinogenesis-and-the-molecular-biology-of-human-cancer.
  • ISBN: 9780203503430
  • Release Date: 2005-10-31
  • Number of pages: 592
  • Author: David Warshawsky
  • Publisher: CRC Press



To gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Fortunately, David Warshawsky and Joseph Landolph Jr., both highly respected for their own contributions to the field, know exactly whom to call upon to fulfill the need for a definitive summary. Molecular Carcinogenesis and the Molecular Biology of Human Cancer provides a technical, as well as historical, overview of research covering the science of cancer. This volume explores molecular information specific to chemical, viral, and radiation carcinogenesis, explains the working of cellular oncogenes and tumor suppressor genes, and also introduces readers to the latest genomic and proteomic approaches. The first part of the book offers basic information; the second part deals strictly with cancer in humans. It commences with discussions on induction and exposure, then reviews complex mixtures of chemical carcinogens, and provides several chapters on tumors, organized by specific organs. This section also covers chemoprevention of chemical carcinogenesis, exposure assessment, and biomarkers, as well as the role of risk assessment, before offering a discussion on prevention that includes the history and particulars of carcinogen regulations. Featuring leading researchers writing about their areas of expertise, this book provides a succinct yet detailed reference that meets the needs of professional researchers, clinicians, and environmental regulators, as well as attorneys practicing law in the area of toxic torts. Its progressive structure allows it to also serve as a primary text or resource for students in medicine and cancer research.

The Biology of Cancer Second Edition

  • Filename: the-biology-of-cancer-second-edition.
  • ISBN: 9781317963462
  • Release Date: 2013-05-14
  • Number of pages: 960
  • Author: Robert Weinberg
  • Publisher: Garland Science



Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

The Molecular Biology of Cancer

  • Filename: the-molecular-biology-of-cancer.
  • ISBN: 9781118430859
  • Release Date: 2013-03-13
  • Number of pages: 632
  • Author: Stella Pelengaris
  • Publisher: John Wiley & Sons



The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. “Bench to Bedside”: A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development and diagnosis through to the treatment and care of cancer patients – essential for providing a broader view of cancer and its impact. The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field. For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information. Key highlights are listed below: An overview of the cancer cell and important new concepts. Selected human cancers: lung, breast, colorectal, prostate, renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a) traditionally important areas such as cell cycle control, growth regulation, oncogenes and tumour suppressors apoptosis, as well as (b) more highly topical areas of apoptosis, telomeres, DNA damage and repair, cell adhesion, angiogenesis, immunity, epigenetics, and the proteasome. Clinical oncology: In-depth coverage of important concepts such as screening, risk of cancer and prevention, diagnoses, managing cancer patients from start to palliative care and end-of-life pathways. Chapters highlighting the direct links between cancer research and clinical applications. New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested. Systems Biology and cutting edge research areas covered such as RNA interference (RNAi). Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review. Quotations have been used in each chapter to introduce basic concepts in an entertaining way. Supported by a dedicated website at www.blackwellpublishing.com/pelengaris We should list the great reviews we got for first edition which are on the back of the 2nd edition: “A capturing, comprehensive, clearly written and absolutely accurate introduction into cancer biology…..This book deserves great praise for the readable presentation of this complex field….the true synthesis of bench and bedside approaches is marvelously achieved.” Christian Schmidt, Molecular Cell “Chapters address the issues of cancer diagnosis, treatment, and patient care and set the book apart from general molecular biology references….This book is applicable to both graduate and undergraduate students, and in the context of a research laboratory, this book would be an excellent resource as a reference guide for scientists at all levels.” V.Emuss, Institute of Cancer Research, London. Also, from the first edition: “Pelengaris, Khan, and the contributing authors are to be applauded. The Molecular Biology of Cancer is a comprehensive and readable presentation of the many faces of cancer from molecular mechanisms to clinical therapies and diagnostics. This book will be welcomed by neophyte students, established scientists in other fields, and curious physicians.” -Dean Felsher, Stanford University

RNA Tumor Viruses Oncogenes Human Cancer and AIDS On the Frontiers of Understanding

  • Filename: rna-tumor-viruses-oncogenes-human-cancer-and-aids-on-the-frontiers-of-understanding.
  • ISBN: 9781461325833
  • Release Date: 2012-12-06
  • Number of pages: 410
  • Author: Philip Furmanski
  • Publisher: Springer Science & Business Media



We stand today on the threshold of a new understanding of cancer. Primarily through the powerful tools of molecular biology, unified hypotheses explaining the origins of the disease are emerging and rapidly being validated. This volume, which presents the latest findings from laboratories throughout the world on the role of RNA tumor viruses in cancer, is a celebration of these achievements and a prediction of further progress leading ultimately to the control of the disease. It is important in this context to recall the natural history or life cycle of RNA cancer virology. From the earliest days of the science, when viruses were first recognized as distinct biologic agents of etiologic significance, their role in cancer was proposed and hotly debated. The critical early discoveries, even those made as recently as 25 years ago, were met with rejection; not skepticism or cautious restraint, but outright rejection. During the 60's, there was a gradual acceptance of the association between viruses and cancer, the result of landmark studies in experimental systems, and this led to a frenzy of activity in the field. There followed another period of doubt and uncertainty, due to the difficulty in attempting to apply directly, and in retrospect inappropriately, the tenets of infectious disease to human cancers, only to have the field resurrected, revitalized and redirected by the explosion of progress in molecular biology and genetics.

Molecular Biology of the Cell

  • Filename: molecular-biology-of-the-cell.
  • ISBN: 0824036956
  • Release Date: 1989
  • Number of pages: 1263
  • Author: Bruce Alberts
  • Publisher: Courier Corporation



New edition of a text in which six researchers from leading institutions discuss what is known and what is yet to be understood in the field of cell biology. The material on molecular genetics has been revised and expanded so that it can be used as a stand-alone text. A new chapter covers pathogens, infection, and innate immunity. Topics include introduction to the cell, basic genetic mechanisms, methods, internal organization of the cell, and cells in their social context. The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.

Human Cancer Viruses

  • Filename: human-cancer-viruses.
  • ISBN: 9783805585767
  • Release Date: 2008-01-01
  • Number of pages: 244
  • Author: John Nicholas
  • Publisher: Karger Medical and Scientific Publishers



The first identification of a tumor-causing virus, Rous sarcoma virus, occurred almost 100 years ago, but it was not until the 1970s that the genetic basis for oncogenesis by this and other acutely transforming retroviruses was appreciated. Since then, numerous viral oncogenes and their corresponding cellular proto-oncogene counterparts have been identified, and these studies have contributed much to our understanding of crucially important aspects of cell biology and transformation.This book provides an up-to-date overview of the 6 major viruses that cause human cancers - HPV, HBV, HCV, EBV, KSHV and HTLV-1 - with respect to their molecular biology and epidemiology and to clinical aspects of disease, therapy and prevention. Contributed by over a dozen internationally renowned scientists, the chapters are comprehensively written and illustrated. The book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to understand the mechanisms leading to cellular transformation and oncogenesis by these viruses as a basis for the development of specific therapeutic and antiviral treatments.

The Molecular Basis of Human Cancer

  • Filename: the-molecular-basis-of-human-cancer.
  • ISBN: 9781597454582
  • Release Date: 2016-11-11
  • Number of pages: 873
  • Author: William B. Coleman
  • Publisher: Humana Press



This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

World Encyclopaedia of Nations and Nationalities

  • Filename: world-encyclopaedia-of-nations-and-nationalities.
  • ISBN: 8171411665
  • Release Date: 1997-01-01
  • Number of pages: 10000
  • Author: E.G. Ravenstein & A.H. Keane
  • Publisher: Discovery Publishing House



The origins and development of the fascinating variety of continents, countries and communities of the world are the engrossing subjects of the present prize set of 17 Vols. in 34 Parts of the encyclopaedia. With marvelously lucid text and equally graphic illustrations, the writers and editors present a panoramic account of the splendid variety of the family of mankind, its numerous and varied habitations, its physical, human and economic geography of man and his activities, and the living dynamic relation that mankind had with fellow communities across land and sea as well as with the planet that sustains all of them. The World Encyclopaedia of Nations and Nationalities opens to students, teachers and general readers a vast and beautiful window onto the great as well as the little known customs, manners and cultures of the world, reveals the universal geographical features and singularities of all countries in the continents, the introduces in vivid detail the many kind of inhabitants that are found world-wide. Not only is this brilliantly conceived encyclopaedia the pride of many libraries across the world, but it is also regarded as an apt companion and complement to the earlier historic work of Darwin, namely, Origin of the Species. In its comprehensive sweep and vibrant treatment the present the present volumes of this encyclopaedia will be an essential part of all libraries.

Molecular Biology of Cancer

  • Filename: molecular-biology-of-cancer.
  • ISBN: 9780199577170
  • Release Date: 2012-04-26
  • Number of pages: 342
  • Author: Lauren Pecorino
  • Publisher: Oxford University Press



The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.

Matters of Life and Death

  • Filename: matters-of-life-and-death.
  • ISBN: 0691002509
  • Release Date: 1998-08
  • Number of pages: 272
  • Author: John Cairns
  • Publisher: Princeton University Press



The last 200 years have altered our life expectations beyond all recognition. But the resulting population explosion threatens what we have gained in scientific progress. In understandable lay terms, Dr. John Cairnsrecently retired from the Harvard School of Public Healthexplains what is known about cancer, molecular biology, and virology, and how new breakthroughs in these areas are likely to affect future generations. Illustrated.

Molecular Toxicology Protocols

  • Filename: molecular-toxicology-protocols.
  • ISBN: 9781592598403
  • Release Date: 2005-01-01
  • Number of pages: 489
  • Author: Phouthone Keohavong
  • Publisher: Springer Science & Business Media



New state-of-the-art molecular techniques promise to transform the field of genetic toxicology by making it possible to directly detect genotoxic exposures and their consequences in humans, to identify the agent(s) involved, and to clinically manage the exposed population. In Molecular Toxicology Protocols, researchers from prominent universities and cancer centers around the world describe in detail their best techniques for analyzing genotoxic exposure and the resulting biological effects, including intermediate biomarkers such as DNA and chromosomal damage, mutations in reporter and oncogenes, and the earliest possible detection of cancer. The authors emphasize analytical methods specifically developed for use in human populations and in cancer patients, or in other in vivo systems such as transgenic mice. Among the applications detailed are the analysis of interactions of chemical and physical agents with cellular macromolecules, especially DNA, the assessment of medically relevant toxicity, and the individualized characterization of genetic damage and repair. There are also methods to assess and characterize the modulation of this damage and repair through individual differences in specific and genome-wide gene expression, including metabolic profiling and apoptotic capacity. These methods mark a shift in emphasis from studies of the agents themselves to the exposed population, and from studies of small populations with significant known exposures to a single agent, to studies of common diseases, such as breast cancer, caused by normal levels of generalized genotoxic exposure. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Molecular Toxicology Protocols offers a gold-standard collection of cutting-edge techniques designed to investigate a broad range of exposures-endogenous, accidental, medical, environmental, and occupational-and their role in human carcinogenesis and other diseases of aging.

Henry s Clinical Diagnosis and Management by Laboratory Methods

  • Filename: henry-s-clinical-diagnosis-and-management-by-laboratory-methods.
  • ISBN: 9781455726844
  • Release Date: 2011-09-06
  • Number of pages: 1568
  • Author: Richard A. McPherson
  • Publisher: Elsevier Health Sciences



Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.

Cancer Cell Culture

  • Filename: cancer-cell-culture.
  • ISBN: 1617790796
  • Release Date: 2011-04-28
  • Number of pages: 502
  • Author: Ian A. Cree
  • Publisher: Humana Press



With many recent advances, cancer cell culture research is more important than ever before. This timely edition of Cancer Cell Culture: Methods and Protocols covers the basic concepts of cancer cell biology and culture while expanding upon the recent shift in cell culture methods from the generation of new cell lines to the use of primary cells. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided for the evaluation of clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Other methods permit the modification of cells for transfection, drug resistance, immortalization, and transfer in vivo, the co-culture of different cell types, and the detection and treatment of contamination. In this new edition, specific emphasis is placed on safe working practice for both cells and laboratory researchers. These chapters contain the information critical to success – only by good practice and quality control will the results of cancer cell culture improve. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Cancer Cell Culture: Methods and Protocols serves as a practical guide for scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this research field.

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