- Filename: evolution-in-health-and-disease.
- ISBN: 0199207461
- Release Date: 2007-11-22
- Number of pages: 398
- Author: Stephen C. Stearns
- Publisher: OUP Oxford
A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.
- Filename: the-story-of-the-human-body.
- ISBN: 0307379418
- Release Date: 2013
- Number of pages: 460
- Author: Daniel Lieberman
- Publisher: Pantheon Books
Examines the key adaptations to the body, discusses how these changes have been both beneficial and harmful, and proposes that many chronic illnesses persist because only the symptoms are being treated.
- Filename: principles-of-evolutionary-medicine.
- ISBN: 9780199663927
- Release Date: 2016-03-17
- Number of pages: 400
- Author: Alan Beedle
- Publisher: Oxford University Press
Evolutionary science is critical to an understanding of integrated human biology and is increasingly recognised as a core discipline by medical and public health professionals. Advances in the field of genomics, epigenetics, developmental biology, and epidemiology have led to the growing realisation that incorporating evolutionary thinking is essential for medicine to achieve its full potential. This revised and updated second edition of the first comprehensive textbook of evolutionary medicine explains the principles of evolutionary biology from a medical perspective and focuses on how medicine and public health might utilise evolutionary thinking. It is written to be accessible to a broad range of readers, whether or not they have had formal exposure to evolutionary science. The general structure of the second edition remains unchanged, with the initial six chapters providing a summary of the evolutionary theory relevant to understanding human health and disease, using examples specifically relevant to medicine. The second part of the book describes the application of evolutionary principles to understanding particular aspects of human medicine: in addition to updated chapters on reproduction, metabolism, and behaviour, there is an expanded chapter on our coexistence with micro-organisms and an entirely new chapter on cancer. The two parts are bridged by a chapter that details pathways by which evolutionary processes affect disease risk and symptoms, and how hypotheses in evolutionary medicine can be tested. The final two chapters of the volume are considerably expanded; they illustrate the application of evolutionary biology to medicine and public health, and consider the ethical and societal issues of an evolutionary perspective. A number of new clinical examples and historical illustrations are included. This second edition of a novel and popular textbook provides an updated resource for doctors and other health professionals, medical students and biomedical scientists, as well as anthropologists interested in human health, to gain a better understanding of the evolutionary processes underlying human health and disease.
- Filename: environmental-epigenomics-in-health-and-disease.
- ISBN: 9783642233807
- Release Date: 2013-05-16
- Number of pages: 302
- Author: Randy L Jirtle
- Publisher: Springer Science & Business Media
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.
- Filename: the-impact-of-early-life-trauma-on-health-and-disease.
- ISBN: 9781139489485
- Release Date: 2010-08-05
- Number of pages:
- Author: Ruth A. Lanius
- Publisher: Cambridge University Press
There is now ample evidence from the preclinical and clinical fields that early life trauma has both dramatic and long-lasting effects on neurobiological systems and functions that are involved in different forms of psychopathology as well as on health in general. To date, a comprehensive review of the recent research on the effects of early and later life trauma is lacking. This book fills an obvious gap in academic and clinical literature by providing reviews which summarize and synthesize these findings. Topics considered and discussed include the possible biological and neuropsychological effects of trauma at different epochs and their effect on health. This book will be essential reading for psychiatrists, clinical psychologists, mental health professionals, social workers, pediatricians and specialists in child development.
- Filename: epigenetics-in-health-and-disease.
- ISBN: 9780132599511
- Release Date: 2012-05-22
- Number of pages: 608
- Author: Igor Kovalchuk
- Publisher: FT Press
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.
- Filename: the-evolution-of-the-human-head.
- ISBN: 9780674046368
- Release Date: 2011-01
- Number of pages: 756
- Author: Daniel Lieberman
- Publisher: Harvard University Press
Dan Lieberman has written an innovative, exhaustively researched and carefully argued book dealing with the evolution of the human head. In it he addresses three interrelated questions. First, why does the human head look the way it does? Second, why did these transformations occur? And third, how is something as complex and vital as the head so variable and evolvable? This book addresses these questions in three sections. The first set of chapters review how human and ape heads grow, both in terms of individual parts (organs and regions) and as an integrated whole. The second section reviews how the head performs its major functions: housing the brain, chewing, swallowing, breathing, vocalizing, thermoregulating, seeing, hearing, tasting, smelling, and balancing during locomotion. The final set of chapters review the fossil evidence for major transformations of the head during human evolution from the divergence of the human and ape lineages through the origins of Homo sapiens. These chapters use developmental and functional insights from the first two sections to speculate on the developmental and selective bases for these transformations.
- Filename: coffee-in-health-and-disease-prevention.
- ISBN: 9780124167162
- Release Date: 2014-11-12
- Number of pages: 1080
- Author: Victor R. Preedy
- Publisher: Academic Press
Coffee in Health and Disease Prevention presents a comprehensive look at the compounds in coffee, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses. No other book on the market considers all the varieties of coffee in one volume, or takes the disease-focused approach that will assist in directing further research and studies. The book embraces a holistic approach and effectively investigates coffee and its specific compounds from the biochemical to the nutritional well-being of geographical populations. This book represents essential reading for researchers in nutrition, dietetics, food science, biochemistry, and public health. Presents one comprehensive, translational source for all aspects of how coffee plays a role in disease prevention and health Experts in nutrition, diet, and food chemistry (from all areas of academic and medical research) take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Focuses on coffee composition; nutritional aspects of coffee; protective aspects of coffee-related compounds; specific coffee components and their effects on tissue and organ systems Features sections on both the general effects of coffee consumption on the body as well as the effects of specific coffee compounds on specific organ systems
- Filename: diseases-and-human-evolution.
- ISBN: 0826330665
- Release Date: 2007
- Number of pages: 484
- Author: Ethne Barnes
- Publisher: UNM Press
Recent interest in new diseases, such as HIV/AIDS and Ebola, and the resurgence of older diseases like tuberculosis has fostered questions about the history of human infectious diseases. How did they evolve? Where did they originate? What natural factors have stalled the progression of diseases or made them possible? How does a microorganism become a pathogen? How have infectious diseases changed through time? What can we do to control their occurrence? Ethne Barnes offers answers to these questions, using information from history and medicine as well as from anthropology. She focuses on changes in the patterns of human behavior through cultural evolution and how they have affected the development of human diseases. Writing in a clear, lively style, Barnes offers general overviews of every variety of disease and their carriers, from insects and worms through rodent vectors to household pets and farm animals. She devotes whole chapters to major infectious diseases such as leprosy, syphilis, smallpox, and influenza. Other chapters concentrate on categories of diseases ("gut bugs," for example, including cholera, typhus, and salmonella). The final chapters cover diseases that have made headlines in recent years, among them mad cow disease, West Nile virus, and Lyme disease. In the tradition of Berton Roueché, Hans Zinsser, and Sherwin Nuland, Ethne Barnes answers questions you never knew you had about the germs that have threatened us throughout human history.
- Filename: ancestors-in-our-genome.
- ISBN: 9780199978038
- Release Date: 2015
- Number of pages: 226
- Author: Eugene E. Harris
- Publisher: Oxford University Press, USA
In 2001, scientists were finally able to determine the full human genome sequence, and with the discovery began a genomic voyage back in time. Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee (2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes is well underway. Researchers are beginning to unravel our full genomic history, comparing it with closely related species to answer age-old questions about how and when we evolved. For the first time, we are finding our own ancestors in our genome and are thereby gleaning new information about our evolutionary past. In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their source among our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer. For example, what does the high level of discordance among the gene trees of humans and the African great apes tell us about our respective separations from our common ancestor? Was our separation from the apes fast or slow, and when and why did it occur? Where, when, and how did our modern species evolve? How do we search across genomes to find the genomic underpinnings of our large and complex brains and language abilities? How can we find the genomic bases for life at high altitudes, for lactose tolerance, resistance to disease, and for our different skin pigmentations? How and when did we interbreed with Neandertals and the recently discovered ancient Denisovans of Asia? Harris draws upon extensive experience researching primate evolution in order to deliver a lively and thorough history of human evolution. Ancestors in Our Genome is the most complete discussion of our current understanding of the human genome available.
- Filename: ancient-bodies-modern-lives.
- ISBN: 0199750548
- Release Date: 2010-05-26
- Number of pages: 272
- Author: Wenda Trevathan, Ph.D.
- Publisher: Oxford University Press
Winner of the 2011 W.W. Howells Book Award of the American Anthropological Association How has bipedalism impacted human childbirth? Do PMS and postpartum depression have specific, maybe even beneficial, functions? These are only two of the many questions that specialists in evolutionary medicine seek to answer, and that anthropologist Wenda Trevathan addresses in Ancient Bodies, Modern Lives. Exploring a range of women's health issues that may be viewed through an evolutionary lens, specifically focusing on reproduction, Trevathan delves into issues such as the medical consequences of early puberty in girls, the impact of migration, culture change, and poverty on reproductive health, and how fetal growth retardation affects health in later life. Hypothesizing that many of the health challenges faced by women today result from a mismatch between how their bodies have evolved and the contemporary environments in which modern humans live, Trevathan sheds light on the power and potential of examining the human life cycle from an evolutionary perspective, and how this could improve our understanding of women's health and our ability to confront health challenges in more creative, effective ways.
- Filename: why-we-get-sick.
- ISBN: 9780307816009
- Release Date: 2012-02-08
- Number of pages: 304
- Author: Randolph M. Nesse
- Publisher: Vintage
The next time you get sick, consider this before picking up the aspirin: your body may be doing exactly what it's supposed to. In this ground-breaking book, two pioneers of the science of Darwinian medicine argue that illness as well as the factors that predispose us toward it are subject to the same laws of natural selection that otherwise make our bodies such miracles of design. Among the concerns they raise: When may a fever be beneficial? Why do pregnant women get morning sickness? How do certain viruses "manipulate" their hosts into infecting others? What evolutionary factors may be responsible for depression and panic disorder? Deftly summarizing research on disorders ranging from allergies to Alzheimer's, and form cancer to Huntington's chorea, Why We Get Sick, answers these questions and more. The result is a book that will revolutionize our attitudes toward illness and will intrigue and instruct lay person and medical practitioners alike. From the Trade Paperback edition.
- Filename: the-evolution-of-medicine.
- ISBN: 1619615096
- Release Date: 2016-09-16
- Number of pages:
- Author: James Maskell
For all too many dedicated physicians, stuck in a cycle of seven-minute patient visits and production line healing, medicine has become a frustrating vocation. Furthermore, the current epidemic of chronic illness demands a new care standard that can break down the existing structural barriers to full resolution. It requires functional medicine. The Evolution of Medicine provides step-by-step instruction for building a successful "community micropractice," one that engages both the patient and practitioner in a therapeutic partnership focused on the body as a whole rather than isolated symptoms. This invaluable handbook will awaken health professionals to exciting new career possibilities. At the same time, it will alleviate the fear of abandoning a conventional medical system that is bad for doctors, patients, and payers, as well as being ineffectual in the treatment of chronic ailments. Welcome to a new world of modern medical care, delivered in a community setting. It's time to embrace the Evolution of Medicine and reignite your love for the art of healing.
- Filename: genomic-elements-in-health-disease-and-evolution.
- ISBN: 9781493930708
- Release Date: 2015-09-30
- Number of pages: 315
- Author: Kyriacos Felekkis
- Publisher: Springer
Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.
- Filename: redox-genome-interactions-in-health-and-disease.
- ISBN: 9780824756611
- Release Date: 2003-09-12
- Number of pages: 640
- Author: Jürgen Fuchs
- Publisher: CRC Press
At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.