Secretory Heat Shock Protein Gp96 Ig Chaperoned Her 2 New Vaccines

  • Filename: secretory-heat-shock-protein-gp96-ig-chaperoned-her-2-new-vaccines.
  • ISBN: OCLC:946630792
  • Release Date: 1999
  • Number of pages: 45
  • Author:
  • Publisher:



The hypothesis that secreted heat shock protein gp96 will trigger an immune response was tested in a tumor system in experimental animals. It was found that gp96 is able to induce tumor specific CD8 CTL without the help of CD4 cells. The postulated molecular and cellular mechanism involves the following steps: 1) gp96-Ig peptide secretion; 2) Binding to endocytosis receptor on dendritic cells; 3) Dendritic cell activation/maturation, including up-regulated expression of CD8O/86; 4) Uptake of gp96 and routing of peptides to endoplasmic reticulum; 5) loading of trimmed peptides on class I MHC molecules and transport to the cell surface; 6) CD8- pre-CTL activation (independent of CD4 T cell help).

The Rational Imagination

  • Filename: the-rational-imagination.
  • ISBN: 0262261847
  • Release Date: 2007-01-26
  • Number of pages: 268
  • Author: Ruth M J. Byrne
  • Publisher: MIT Press



The human imagination remains one of the last uncharted terrains of the mind. This accessible and original monograph explores a central aspect of the imagination, the creation of counterfactual alternatives to reality, and claims that imaginative thoughts are guided by the same principles that underlie rational thoughts. Research has shown that rational thought is more imaginative than cognitive scientists had supposed; in The Rational Imagination, Ruth Byrne argues that imaginative thought is more rational than scientists have imagined.People often create alternatives to reality and imagine how events might have turned out "if only" something had been different. Byrne explores the "fault lines" of reality, the aspects of reality that are more readily changed in imaginative thoughts. She finds that our tendencies to imagine alternatives to actions, controllable events, socially unacceptable actions, causal and enabling relations, and events that come last in a temporal sequence provide clues to the cognitive processes upon which the counterfactual imagination depends. The explanation of these processes, Byrne argues, rests on the idea that imaginative thought and rational thought have much in common.

Phylogenetic Perspectives on the Vertebrate Immune System

  • Filename: phylogenetic-perspectives-on-the-vertebrate-immune-system.
  • ISBN: 9781461512912
  • Release Date: 2012-12-06
  • Number of pages: 383
  • Author: J. M. Becker
  • Publisher: Springer Science & Business Media



This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.

Issues in Immunology Research 2011 Edition

  • Filename: issues-in-immunology-research-2011-edition.
  • ISBN: 9781464964046
  • Release Date: 2012-01-09
  • Number of pages: 1986
  • Author:
  • Publisher: ScholarlyEditions



Issues in Immunology Research / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Immunology Research. The editors have built Issues in Immunology Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Immunology Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Immunology Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Chaperoned

  • Filename: chaperoned.
  • ISBN: 1611090245
  • Release Date: 2012
  • Number of pages: 388
  • Author: Dora Heldt
  • Publisher: Amazoncrossing



Thirty years have passed since Christine and her father Heinz had a disasterous vacation together, when her father left her at a gas station to teach her a lesson. But now Christine's mother is insisting that Christine and her best friend, Dorothea, take Heinz along on a relaxing girls' trip to the beach. Will this vacation also be a disaster? Or will Christine realize that she many not be too grown up to need her father?

Membrane Transport Proteins Advances in Research and Application 2012 Edition

  • Filename: membrane-transport-proteins-advances-in-research-and-application-2012-edition.
  • ISBN: 9781464996337
  • Release Date: 2012-12-26
  • Number of pages: 258
  • Author:
  • Publisher: ScholarlyEditions



Membrane Transport Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Membrane Transport Proteins. The editors have built Membrane Transport Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Membrane Transport Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Membrane Transport Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Heat Shock Protein Based Therapies

  • Filename: heat-shock-protein-based-therapies.
  • ISBN: 9783319172118
  • Release Date: 2015-07-22
  • Number of pages: 385
  • Author: Alexzander A. A. Asea
  • Publisher: Springer



The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Studies in the Composition and Decomposition of Event Predicates

  • Filename: studies-in-the-composition-and-decomposition-of-event-predicates.
  • ISBN: 9789400759831
  • Release Date: 2013-02-26
  • Number of pages: 252
  • Author: Boban Arsenijević
  • Publisher: Springer Science & Business Media



This detailed, perceptive addition to the linguistics literature analyzes the semantic components of event predicates, exploring their fine-grained elements as well as their agency in linguistic processing. The papers go beyond pure semantics to consider their varying influences of event predicates on argument structure, aspect, scalarity, and event structure. The volume shows how advances in the linguistic theory of event predicates, which have spawned Davidsonian and neo-Davidsonian notions of event arguments, in addition to ‘event structure’ frameworks and mereological models for the eventuality domain, have sidelined research on specific sets of entailments that support a typology of event predicates. Addressing this imbalance in the literature, the work also presents evidence indicating a more complex role for scalar structures than currently assumed. It will enrich the work of semanticists, psycholinguists, and syntacticians with a decompositional approach to verb phrase structure.

Role of Cytosolic Chaperone HSP90 HSP90AA1 AB1 in Antigen Presentation by MHC I Molecules

  • Filename: role-of-cytosolic-chaperone-hsp90-hsp90aa1-ab1-in-antigen-presentation-by-mhc-i-molecules.
  • ISBN: 9781109074741
  • Release Date: 2009
  • Number of pages: 119
  • Author:
  • Publisher: ProQuest



Antigen presentation by MHC I molecules involves generation of peptides, loading of MHC I with peptides, and transport of MHC I-peptide complexes to the cell surface. The peptides are derived from the degradation of endogenous proteins in the cytosol. In this thesis, the chicken ovalbumin epitope SIINFEKL has been used as the model antigen and mechanism of its generation has been investigated. My results show that complete inhibition of proteasome activity results in only a modest inhibition in generation of new Kb-SIINFEHL complexes. Only a combined inhibition of proteasomes and other cytosolic proteases leads to a complete inhibition of generation of such complexes. Subsequent to their generation, peptides are chaperoned by heat shock proteins (HSPs). My studies provide direct evidence for the involvement of cytosolic hsp90 in chaperoning of peptides that are destined for loading onto MHC I. My studies define the nature of the peptides chaperoned by hsp90, and the precise step at which hsp90 associates with peptides. The role of hsp90 in presentation of an ovalbumin epitope is found to be at a post-proteasomal step: hsp90 associates with N-terminally extended precursors of the SIINFEHL epitope, and such peptides are depleted from hsp90 preparations in inhibitor-treated cells. My results indicate that treatment of cells with hsp90 inhibitors leads to generation of "empty" MHC I due to inhibited loading of MHC I with peptides. Hsp90-inhibited cells are poor stimulators of T lymphocytes. Altogether, these results define the mechanisms of generation of SIINFEHL or its precursors from intact ovalbumin, and the chaperoning of such precursors by hsp90. In addition, the role of hsp90 in processing of a variety of antigens, such as epitope I of larger T antigen is shown. I have also examined the form of the antigen, which is transferred from an antigen donor cell to an antigen presenting cell during cross-priming. My results are consistent with the idea that peptides, rather than the intact protein constitute the transferred form of antigen.

The Macrophage as Therapeutic Target

  • Filename: the-macrophage-as-therapeutic-target.
  • ISBN: 9783642557422
  • Release Date: 2012-12-06
  • Number of pages: 496
  • Author: Siamon Gordon
  • Publisher: Springer Science & Business Media



During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.

Retinal Pharmacotherapeutics

  • Filename: retinal-pharmacotherapeutics.
  • ISBN: 9783318055658
  • Release Date: 2015-10-27
  • Number of pages: 408
  • Author: Q.D. Nguyen
  • Publisher: Karger Medical and Scientific Publishers



The use of pharmacotherapeutics in the management of retinal diseases is rapidly evolving, and a favorable therapy for the patient. Today anti-VEGF agents are used for a range of indications from inflammation-related choroidal neovascularization to macular edema secondary to retinal vein occlusion or diabetic retinopathy. Beyond VEGF, there is an array of target areas under investigation – not only for vascular pathologies such as age-related macular degeneration and diabetic eye disease, but also for degenerative, infectious and inflammatory retinal conditions. This publication discusses many aspects from basic research on the retina, to animal models for retinal drug delivery, retinal diseases that are amenable to pharmacotherapy and also drugs and mechanisms in retinal diseases. Anyone concerned with the management of retinal diseases - the general ophthalmologist and the retina specialist alike – will find this book indispensable reading.

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