Cancer Drug Design and Discovery

  • Filename: cancer-drug-design-and-discovery.
  • ISBN: 9780123972286
  • Release Date: 2013-09-30
  • Number of pages: 640
  • Author: Stephen Neidle
  • Publisher: Academic Press



Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research. Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources

Cancer Drug Design and Discovery

  • Filename: cancer-drug-design-and-discovery.
  • ISBN: 0080554954
  • Release Date: 2011-04-28
  • Number of pages: 496
  • Author: Stephen Neidle
  • Publisher: Academic Press



The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

Textbook of Drug Design and Discovery Third Edition

  • Filename: textbook-of-drug-design-and-discovery-third-edition.
  • ISBN: 9780203301371
  • Release Date: 2003-08-02
  • Number of pages: 592
  • Author: Tommy Liljefors
  • Publisher: CRC Press



Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Principles of Anticancer Drug Development

  • Filename: principles-of-anticancer-drug-development.
  • ISBN: 1441973583
  • Release Date: 2010-12-29
  • Number of pages: 674
  • Author: Elizabeth Garrett-Mayer
  • Publisher: Springer Science & Business Media



A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Medicinal Chemistry of Anticancer Drugs

  • Filename: medicinal-chemistry-of-anticancer-drugs.
  • ISBN: 008055962X
  • Release Date: 2008-06-04
  • Number of pages: 400
  • Author: Carmen Avendano
  • Publisher: Elsevier



Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

HIV 1 Integrase

  • Filename: hiv-1-integrase.
  • ISBN: 9781118015360
  • Release Date: 2011-08-10
  • Number of pages: 520
  • Author: Nouri Neamati
  • Publisher: John Wiley & Sons



This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

Frontiers in Drug Design and Discovery

  • Filename: frontiers-in-drug-design-and-discovery.
  • ISBN: 9781608052035
  • Release Date: 2010-01-01
  • Number of pages: 206
  • Author: Atta-ur Rahman
  • Publisher: Bentham Science Publishers



"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. the Ebook series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery. the Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Quantitative Structure Activity Relationships in Drug Design Predictive Toxicology and Risk Assessment

  • Filename: quantitative-structure-activity-relationships-in-drug-design-predictive-toxicology-and-risk-assessment.
  • ISBN: 9781466681378
  • Release Date: 2015-02-28
  • Number of pages: 727
  • Author: Roy, Kunal
  • Publisher: IGI Global



Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Anticancer Drug Development Guide

  • Filename: anticancer-drug-development-guide.
  • ISBN: 9781592597390
  • Release Date: 2004-02-01
  • Number of pages: 451
  • Author: Beverly A. Teicher
  • Publisher: Springer Science & Business Media



This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Tumor Models in Cancer Research

  • Filename: tumor-models-in-cancer-research.
  • ISBN: 1607619687
  • Release Date: 2010-12-01
  • Number of pages: 693
  • Author: Beverly A. Teicher
  • Publisher: Springer Science & Business Media



The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Textbook of Drug Design and Discovery Fourth Edition

  • Filename: textbook-of-drug-design-and-discovery-fourth-edition.
  • ISBN: 9781439882405
  • Release Date: 2009-10-07
  • Number of pages: 476
  • Author: Kristian Stromgaard
  • Publisher: CRC Press



The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, Textbook of Drug Design and Discovery, Fourth Edition describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease. This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery. Extensively revised, new topics in the fourth edition include: Biostructure-based and ligand-based drug design Chemical biology Natural products Imaging Neurotransmitter transporters Opioid and cannabinoid receptors Hypnotics Neglected diseases Immunomodulating agents Antibiotics The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design.

Systems Biology in Cancer Research and Drug Discovery

  • Filename: systems-biology-in-cancer-research-and-drug-discovery.
  • ISBN: 9789400748187
  • Release Date: 2012-09-29
  • Number of pages: 424
  • Author: Asfar S Azmi
  • Publisher: Springer Science & Business Media



Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.

New Approaches in Cancer Pharmacology Drug Design and Development

  • Filename: new-approaches-in-cancer-pharmacology-drug-design-and-development.
  • ISBN: 9783642790881
  • Release Date: 2012-12-06
  • Number of pages: 97
  • Author: Paul Workman
  • Publisher: Springer Science & Business Media



The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.

The Search for New Anticancer Drugs

  • Filename: the-search-for-new-anticancer-drugs.
  • ISBN: 079238959X
  • Release Date: 1992-11-30
  • Number of pages: 296
  • Author: Michael Waring
  • Publisher: Springer Science & Business Media



Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought.

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